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New piece found in the puzzle of epigenetics

Biology / Cell & Microbiology

created Jun 16, 2009 | popularity 5 / 5 (8) | comments 0

For many years scientists have known that the numerous biological functions of an organism are not regulated solely by the DNA sequence of its genes: Superordinate regulatory mechanisms exist that contribute to determining ...


How RNA polymerase II gets the go-ahead for gene transcription

Biology / Cell & Microbiology

created Oct 09, 2009 | popularity not rated yet | comments 0

All cells perform certain basic functions. Each must selectively transcribe parts of the DNA that makes up its genome into RNAs that specify the structure of proteins. The set of proteins synthesized by a cell in turn determines ...


Scientists discover dynamics of transcription in living mammalian cells

Biology /

created Aug 06, 2007 | popularity 5 / 5 (6) | comments 1

Transcription — the transfer of DNA’s genetic information through the synthesis of complementary molecules of messenger RNA — forms the basis of all cellular activities. Yet little is known about the dynamics of the process ...


Gene transcribing machine takes halting, backsliding trip along the DNA

Gene transcribing machine takes halting, backsliding trip along the DNA

Chemistry / Biochemistry

created Jul 30, 2009 | popularity 5 / 5 (4) | comments 1

(PhysOrg.com) -- The body's nanomachines that read our genes don't run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists.


Plant polymerases IV and V are special forms of Polymerase II

Plant polymerases IV and V are special forms of Polymerase II

Biology /

created Jan 06, 2009 | popularity 5 / 5 (3) | comments 0

(PhysOrg.com) -- It's a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA ...


Lab identifies new role for factor critical to transcription

Biology /

created Jun 17, 2008 | popularity 4.5 / 5 (2) | comments 0

The Stowers Institute's Shilatifard Lab has identified a new role for the elongation factor ELL in gene transcription by RNA polymerase II (Pol II) — the enzyme that synthesizes messenger RNA to carry genetic information ...


Research sheds light on the mechanics of gene transcription

Research sheds light on the mechanics of gene transcription

Biology /

created Jan 08, 2008 | popularity 4 / 5 (5) | comments 0

The molecular machinery behind gene transcription -- the intricate transfer of information from a segment of DNA to a corresponding strand of messenger RNA -- isn't stationed in special "transcription factories" ...


How cell's master transcribing machine achieves near perfection

Biology /

created Jun 05, 2008 | popularity 3.7 / 5 (3) | comments 0

One of the most critical processes in biology is the transcription of genetic information from DNA to messenger RNA (mRNA), which provides the blueprint for the proteins that form the machinery of life. Now, researchers have ...


Evolution with a restricted number of genes

Biology /

created Dec 14, 2007 | popularity 4.7 / 5 (3) | comments 0

The development of higher forms of life would appear to have been influenced by RNA polymerase II. This enzyme transcribes the information coded by genes from DNA into messenger-RNA (mRNA), which in turn is the basis for ...


A new look at how genes unfold to enable their expression

A new look at how genes unfold to enable their expression

Biology /

created Jul 14, 2008 | popularity 4.5 / 5 (13) | comments 0

(PhysOrg.com) -- Cornell researchers have uncovered surprising new information about the process by which genes are unwrapped and exposed so that they can be expressed.


Molecule stops DNA replication in its tracks

Molecule stops DNA replication in its tracks

Biology /

created Oct 20, 2008 | popularity 4 / 5 (3) | comments 0

(PhysOrg.com) -- When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers ...


Bird flu leaves the nest -- adapting to a new host

Medicine & Health / Research

created Aug 26, 2009 | popularity not rated yet | comments 0

Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. The related report by Gabriel et al, "Spread of Infection and Lymphocyte Depletion in Mice Depends on ...


Researchers study virus with unusual properties

Researchers study virus with unusual properties

Biology /

created Dec 08, 2008 | popularity 4.7 / 5 (14) | comments 0

(PhysOrg.com) -- A team of researchers from Penn State University and the University of Chicago has uncovered clues that may explain how and why a particular virus, called N4, injects an unusual substance ...


Molecular typesetting -- proofreading without a proofreader

Biology / Cell & Microbiology

created Jun 23, 2009 | popularity 5 / 5 (1) | comments 0

Researchers at the Universities of Leeds and Bristol (UK) have developed a model of how errors are corrected whilst proteins are being built.


How 'molecular machines' kick start gene activation revealed

Biology /

created Nov 06, 2008 | popularity 4.8 / 5 (4) | comments 0

How 'molecular machines' inside cells swing into action to activate genes at different times in a cell's life is revealed today in new research published in Molecular Cell.