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Rewrite the textbooks: Transcription is bidirectional

Biology /

created Jan 25, 2009 | popularity 4.6 / 5 (9) | comments 1

Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. The same is true for many other organisms that are easier ...


Reversing the conventional DNA wisdom

Biology /

created Dec 04, 2008 | popularity 4.3 / 5 (18) | comments 2

(PhysOrg.com) -- The copying of DNA's master instructions into messenger molecules of RNA, a process known as DNA transcription, has always been thought to be a unidirectional process whereby a copying machine starts and ...


Scientists develop tool to study a deadly parasite’s histone code

Biology / Cell & Microbiology

created May 14, 2009 | popularity 4.5 / 5 (2) | comments 0

(PhysOrg.com) -- In the Japanese art of paper folding, a series of folds can make the same sheet of paper into a ballerina or baby elephant. But try unfolding the baby elephant and making it into a ballerina. It’s like trying ...


How RNA polymerase II gets the go-ahead for gene transcription

Biology / Cell & Microbiology

created Oct 09, 2009 | popularity not rated yet | comments 0

All cells perform certain basic functions. Each must selectively transcribe parts of the DNA that makes up its genome into RNAs that specify the structure of proteins. The set of proteins synthesized by a cell in turn determines ...


Putting microRNAs on the stem cell map

Biology /

created Aug 07, 2008 | popularity 5 / 5 (2) | comments 0

Embryonic stem cells are always facing a choice—either to self-renew or begin morphing into another type of cell altogether. It's a tricky choice, governed by complex gene regulatory circuitry driven by a handful of key regulators ...


No-entry zones for AIDS virus

No-entry zones for AIDS virus

Medicine & Health / HIV & AIDS

created Nov 12, 2009 | popularity not rated yet | comments 0

The AIDS virus inserts its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center have now shown for the first time that the virus almost entirely spares particular ...


Gene regulation in humans is closer than expected to simple organisms

Medicine & Health / Research

created Aug 29, 2007 | popularity 4.5 / 5 (8) | comments 0

Using a novel method developed to identify reliably functional binding motifs, researchers from the Weizmann Institute of Science in Israel have performed a genome-wide study of functional human transcription factor binding ...


Transcription factors guide differences in human and chimp brain function

Transcription factors guide differences in human and chimp brain function

Biology / Cell & Microbiology

created Dec 07, 2009 | popularity 5 / 5 (2) | comments 0

Humans share at least 97 percent of their genes with chimpanzees, but, as a new study of transcription factors makes clear, what you have in your genome may be less important than how you use it.


Gene regulates immune cells' ability to harm the body

Medicine & Health / Research

created Jul 17, 2009 | popularity 5 / 5 (2) | comments 0

A recently identified gene allows immune cells to start the self-destructive processes thought to underlie autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis, researchers at Washington University ...


Genetic discovery could lead to advances in dental treatment

Medicine & Health / Genetics

created Feb 23, 2009 | popularity 5 / 5 (4) | comments 0

Researchers have identified the gene that ultimately controls the production of tooth enamel, a significant advance that could some day lead to the repair of damaged enamel, a new concept in cavity prevention, and restoration ...


Scientists identify key roadblock to gene expression

Scientists identify key roadblock to gene expression

Biology /

created May 08, 2008 | popularity 3.2 / 5 (6) | comments 0

A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster. ...


Toward new drugs that turn genes on and off

Toward new drugs that turn genes on and off

Chemistry / Biochemistry

created Jun 04, 2009 | popularity 5 / 5 (6) | comments 0

Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, ...


Early-stage gene transcription creates access to DNA

Medicine & Health / Genetics

created Oct 06, 2008 | popularity 5 / 5 (4) | comments 0

A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, ...


Researchers revise long-held theory of fruit-fly development

Researchers revise long-held theory of fruit-fly development

Biology / Cell & Microbiology

created Dec 17, 2009 | popularity not rated yet | comments 0

For decades, science texts have told a simple and straightforward story about a particular protein—a transcription factor—that helps the embryo of the fruit fly, Drosophila melanogaster, pattern tissues in a m ...


How cells change gears: New insights published in Nature Genetics

How cells change gears

Medicine & Health / Genetics

created Apr 20, 2009 | popularity not rated yet | comments 0

Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." This computational biology work from the ...