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Clearer day for gene therapy: New vector carries big genes linked to inherited blindness
Apr 16, 2008 |
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For some inherited diseases, one barrier to successful gene therapy is that a commonly used vector (package into which the curative gene is placed) cannot accommodate the large size of the curative gene. However, a newly ...
Researchers discover how mosquitoes avoid succumbing to viruses they transmit
Biology /
Dec 01, 2008 |
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Mosquitoes are like Typhoid Mary. They can spread viruses which cause West Nile fever, dengue fever, or yellow fever without themselves getting sick. Scientists long thought that the mosquito didn't care whether it had a ...
Study offers insights into failed HIV-1 vaccine trial
Medicine & Health / HIV & AIDS
Jul 20, 2009 |
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Following the disbandment of the STEP trial to test the efficacy of the Merck HIV-1 vaccine candidate in 2007, the leading explanation for why the vaccine was ineffective - and may have even increased susceptibility to acquiring ...
Virus used to create experimental HIV vaccines directly impairs the immune response
Medicine & Health / HIV & AIDS
Nov 15, 2007 |
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Leading efforts to create an HIV vaccine have hinged on the use of viruses as carriers for selected elements of the HIV virus. Recently, however, evidence has emerged that some of these so-called viral vector systems may ...
Human Movement Plays Critical Role in Disease Transmission
Jul 21, 2009 |
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To control mosquito-borne diseases like dengue, researchers need to look at the behavior of people, not just the insect that transmits the disease, according to new research by Steven Stoddard of the University ...
A novel finding in how chikungunya virus has spread to new vectors and locations
Biology /
Dec 07, 2007 |
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Researchers at the University of Texas Medical Branch have discovered how a key protein switch allows Chikungunya Virus (CHIKV) to spread to new vectors. The study, published December 7 in PLoS Pathogens, explains how the ...
Converting adult somatic cells to pluripotent stem cells using a single virus
Biology /
Jan 07, 2009 |
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A Boston University School of Medicine-led research team has discovered a more efficient way to create induced Pluripotent Stem (iPS) cells, derived from mouse fibroblasts, by using a single virus vector instead of multiple ...
Clinical trial will test new HIV/AIDS vaccine
Medicine & Health / HIV & AIDS
Apr 03, 2008 |
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A phase 1 clinical trial to test a novel HIV/AIDS vaccine has begun at Brigham and Women’s Hospital (BWH). This new vaccine aims to overcome the problem of preexisting immunity to common vaccine vectors, which is thought ...
Whitefly spreads emerging plant viruses
Biology /
Jan 18, 2007 |
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A tiny whitefly is responsible for spreading a group of plant viruses that cause devastating disease on food, fiber, and ornamental crops, say plant pathologists with The American Phytopathological Society (APS).
Researcher eliminates viral vector in stem cell reprogramming
Oct 10, 2008 |
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Shinya Yamanaka MD, PhD, of Kyoto University and the Gladstone Institute of Cardiovascular Disease (GICD) has taken another step forward in improving the possibilities for the practical application of induced pluripotent ...
Researchers examine possible implications of daily commute and mosquito-borne diseases
Sep 18, 2009 |
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University of Hawaii at Manoa assistant researcher Durrell Kapan recently published a paper, 'Man Bites Mosquito: Understanding the Contribution of Human Movement to Vector-Borne Disease Dynamics,' in PLoS One. Published August ...
New research may help to design better gene therapy vectors
Biology /
Oct 07, 2008 |
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(PhysOrg.com) -- Research published by scientists from the University of Reading may offer an insight into ways of making safer and more specific gene therapy vectors. The research, published in the journal Nature Structural an ...
Discovery could lead to better rice yields
Biology /
Feb 10, 2009 |
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(PhysOrg.com) -- Building on plant virus research started more than 20 years ago, a biologist at Washington University in St. Louis and his a colleague at the Donald Danforth Plant Science Center in St. Louis ...
Gene therapy technique slows ALD brain disease
Nov 05, 2009 |
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A strategy that combines gene therapy with blood stem cell therapy may be a useful tool for treating a fatal brain disease, French researchers have found. These findings appear in the 6 November 2009 issue ...
Gene therapy for chronic pain gets first test in people
Sep 15, 2008 |
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This week, University of Michigan scientists will begin a phase 1 clinical trial for the treatment of cancer-related pain, using a novel gene transfer vector injected into the skin to deliver a pain-relieving ...
