Acute lymphoblastic leukemia
hideAcute lymphoblastic leukemia (ALL), is a form of leukemia, or cancer of the white blood cells characterized by excess lymphoblasts.
Malignant, immature white blood cells continuously multiply and are overproduced in the bone marrow. ALL causes damage and death by crowding out normal cells in the bone marrow, and by spreading (metastasizing) to other organs. ALL is most common in childhood with a peak incidence at 4–12 years of age, and another peak in old age. The overall cure rate in children is 85%, and about 50% of adults have long-term disease-free survival. 'Acute' refers to the undifferentiated, immature state of the circulating lymphocytes ("blasts"), and to the rapid progression of disease, which can be fatal in weeks to months if left untreated.
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News tagged with acute lymphoblastic leukemia
Researchers find two units of umbilical cord blood reduce risk of leukemia recurrence
Nov 13, 2009 |
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A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease ...
Researchers 'notch' a victory toward new kind of cancer drug
Nov 11, 2009 |
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(PhysOrg.com) -- Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed. Their discovery, published in ...
New chromosomal abnormality identified in leukemia associated with Down syndrome
Oct 18, 2009 |
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Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children ...
New treatment more than doubles survival for high risk childhood leukemia
Oct 06, 2009 |
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Results of a phase two clinical trial published October 5th in the Journal of Clinical Oncology show that adding continuous daily doses of a targeted drug called imatinib mesylate to regular chemotherapy more than double ...
Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia
Aug 16, 2009 |
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Scientists at St. Jude Children's Research Hospital have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia (ALL), including a gene that may help predict drug ...
Common household pesticides linked to childhood cancer cases in Washington area
Jul 28, 2009 |
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A new study by researchers at the Georgetown's Lombardi Comprehensive Cancer Center finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops ...
Breast cancer drug shows promise against serious infections
Jul 20, 2009 |
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An FDA-approved drug used for preventing recurrence of breast cancer shows promise in fighting life-threatening fungal infections common in immune-compromised patients, such as infants born prematurely and patients with cancer. ...
New strategy in tumor treatment
Jul 20, 2009 |
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A new strategy proposed by researchers at Dartmouth Medical School and Amtek, Hanover, NH may treat tumors that do not respond to conventional treatment. The study, which was published on May 29th in the open access, peer ...
Study identifies first molecular steps to childhood leukemia
Jul 15, 2009 |
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A Massachusetts General Hospital (MGH)-based research team has identified how a chromosomal abnormality known to be associated with acute lymphoblastic leukemia (ALL) - the most common cancer in children - initiates the disease ...
Pediatric acute lymphoblastic leukemia is curable without preventive cranial radiation
Jun 24, 2009 |
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Childhood acute lymphoblastic leukemia (ALL) can be successfully treated using a carefully personalized chemotherapy regimen without cranial radiation, investigators at St. Jude Children's Research Hospital have found. Such ...
Cancer Researchers Identify New Mutant Genes
Jun 03, 2009 |
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(PhysOrg.com) -- University of New Mexico Cancer Center researchers have identified a genetic mutation underlying one of the most common childhood cancers, acute lymphoblastic leukemia (ALL). The discovery could lead to more ...
Mutant genes in high-risk childhood leukemias identified
May 19, 2009 |
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A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblastic leukemia (ALL) that have a high risk of relapse and death. The finding suggests specific drugs that could ...
New genes involved in acute lymphoblastic leukemia play fundamental role in prognosis of the disease
Feb 06, 2009 |
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The inactivity or "silence" of certain genes plays a fundamental role in the prognosis of acute lymphoblastic leukemia as well as in response to treatment, according to the results of research involving a ...
