Serum amyloid A (SAA) is a family of ancient proteins that can be traced from present-day humans back half a billion years to sea cucumbers and oysters. A new study by researchers from the Boston University Chobanian & Avedisian ...
Molecular & Computational biology
Aug 22, 2023
0
19
A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases. The study, published in Nature Communications, offers key insights that could ...
Biochemistry
Mar 27, 2023
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19
Nanomaterials inspired by amyloid proteins are gaining interest in nanotechnology, due to their modularity, controlled self-assembly and stability. A key advantage of these materials is the possibility of incorporating protein ...
Bio & Medicine
Feb 28, 2023
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66
A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors. This amyloid protein, α-S1 casein, normally plays a vital ...
Molecular & Computational biology
Jan 24, 2023
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7
Inside a living cell, proteins and other molecules are often tightly packed together. These dense clusters can be difficult to image because the fluorescent labels used to make them visible can't wedge themselves in between ...
Bio & Medicine
Aug 29, 2022
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138
Protein function and activity are determined by both their assembly and secondary structure. Abnormalities related to either protein aggregation or secondary structure can lead to neurodegenerative diseases. In a new study, ...
Bio & Medicine
Jul 14, 2022
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10
It is now possible to deliver therapeutics based on short interfering RNAs to hepatocytes; however, new delivery solutions are necessary to target additional organs. In a new report now published in Nature Biotechnology, ...
Amyloidosis is a multifaceted disease group caused by deposits of the misfolded "amyloid" protein in various tissues. Amyloid protein is very unique compared to other native proteins in that it has a cross-β-sheet structure, ...
Veterinary medicine
Oct 7, 2021
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4
Spider silk is said to be one of the strongest, toughest materials on the Earth. Now engineers at Washington University in St. Louis have designed amyloid silk hybrid proteins and produced them in engineered bacteria. The ...
Nanomaterials
Jul 21, 2021
1
4555
Correct, or native, protein folding is essential for correct protein function. Protein misfolding can lead to the formation of amyloid fibrils, and amyloidosis, which is implicated in various human neurodegenerative diseases, ...
Biotechnology
Feb 1, 2021
0
197
