Related topics: immune system , proceedings of the national academy of sciences , virus , hiv , vaccine
Antibody
hideAntibodies (also known as immunoglobulins, abbreviated Ig) are gamma globulin proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses. They are typically made of basic structural units—each with two large heavy chains and two small light chains—to form, for example, monomers with one unit, dimers with two units or pentamers with five units. Antibodies are produced by a kind of white blood cell called a plasma cell. There are several different types of antibody heavy chains, and several different kinds of antibodies, which are grouped into different isotypes based on which heavy chain they possess. Five different antibody isotypes are known in mammals, which perform different roles, and help direct the appropriate immune response for each different type of foreign object they encounter.
Although the general structure of all antibodies is very similar, a small region at the tip of the protein is extremely variable, allowing millions of antibodies with slightly different tip structures, or antigen binding sites, to exist. This region is known as the hypervariable region. Each of these variants can bind to a different target, known as an antigen. This huge diversity of antibodies allows the immune system to recognize an equally wide diversity of antigens. The unique part of the antigen recognized by an antibody is called an epitope. These epitopes bind with their antibody in a highly specific interaction, called induced fit, that allows antibodies to identify and bind only their unique antigen in the midst of the millions of different molecules that make up an organism. Recognition of an antigen by an antibody tags it for attack by other parts of the immune system. Antibodies can also neutralize targets directly by, for example, binding to a part of a pathogen that it needs to cause an infection.
The large and diverse population of antibodies is generated by random combinations of a set of gene segments that encode different antigen binding sites (or paratopes), followed by random mutations in this area of the antibody gene, which create further diversity. Antibody genes also re-organize in a process called class switching that changes the base of the heavy chain to another, creating a different isotype of the antibody that retains the antigen specific variable region. This allows a single antibody to be used by several different parts of the immune system. Production of antibodies is the main function of the humoral immune system.
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News tagged with antibodies
Deadly infection more common than realized
Dec 22, 2009 |
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Staphylococcus aureus causes far more serious infections than previously realised, with more than 3,000 Swedes affected every year, reveals a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden.
Study shows immune system protein involved in reprogramming adult cells to express stem cell genes
Dec 22, 2009 |
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(PhysOrg.com) -- Scientists have discovered a protein required to quickly and efficiently reprogram human skin cells to express embryonic stem cell genes.
One dose of H1N1 vaccine may provide sufficient protection for infants and children
Dec 21, 2009 |
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One dose of vaccine may be effective to protect infants and children and reduce transmission of the H1N1 virus, according to a study in JAMA, published online today because of its public health implications. The study will a ...
Major breakthrough may pave the way for therapeutic vaccines
Dec 17, 2009 |
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It should be possible to use therapeutic vaccines to create both cheap and effective drugs for diseases like cancer and allergies. One problem in developing such vaccines has previously been the lack of adjuvants, substances ...
26 operations, 13 kidneys: hope to few with little
Dec 14, 2009 |
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(AP) -- Twenty-six operations put healthy kidneys into 13 desperately ill people: Doctors in the nation's capital just performed a record-setting kidney swap, part of a pioneering effort to expand transplants ...
Antibody-guided drug shows encouraging activity in metastatic breast cancer
Dec 12, 2009 |
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A new antibody-drug compound shrank or halted the growth of metastatic breast tumors in almost half of a group of patients whose HER2-positive cancer had become resistant to standard therapies, according to early data from ...
Researchers Build Artificial Immune System to Solve Computational Problems
Technology / Computer Sciences
Dec 03, 2009 |
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(PhysOrg.com) -- By mimicking the way that a living body acquires immunity to disease through vaccination, researchers have designed an artificial immune system to solve optimization problems more effectively ...
Aspirin, tylenol may decrease effectiveness of vaccines
Dec 01, 2009 |
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With flu season in full swing and the threat of H1N1 looming, demand for vaccines is at an all-time high. Although those vaccines are expected to be effective, University of Missouri researchers have found further evidence ...
Tiny magnetic discs could kill cancer cells: study
Nanotechnology / Bio & Medicine
Nov 29, 2009 |
3.8 / 5 (23) |
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Tiny magnetic discs just a millionth of a metre in diameter could be used to used to kill cancer cells, according to a study published on Sunday.
New cancer target for non-Hodgkin's lymphoma
Nov 22, 2009 |
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Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, ...
Researchers discover antibody receptor identity, propose renaming immune-system gene
Nov 20, 2009 |
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Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on ...
Scientists identify DNA that regulates antibody production
Nov 20, 2009 |
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(PhysOrg.com) -- When foreign invaders trip the immune system’s alarm, antibodies need to be specially sculpted to attack them head on. New research now shows that gene segments called enhancers control the reshuffling of ...
Vaccine being developed to help smokers quit
Medicine & Health / Medications
Nov 20, 2009 |
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(PhysOrg.com) -- Glaxo-SmithKline has joined forces with Nabi Pharmaceuticals to produce a vaccine to help smokers give up their addiction permanently.
New findings suggest strategy to help generate HIV-neutralizing antibodies
Medicine & Health / HIV & AIDS
Nov 19, 2009 |
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New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute ...
Scientists explain binding action of 2 key HIV antibodies; could lead to new vaccine design
Nov 09, 2009 |
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A very close and detailed study of how the most robust antibodies work to block the HIV virus as it seeks entry into healthy cells has revealed a new direction for researchers hoping to design an effective vaccine.
