New research could pave the way to developing cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death. Cancer cells that are resistant to anticancer drugs are known to be vulnerable to ferroptosis. ...
Biotechnology
Apr 5, 2024
0
50
Many important medicines, such as antibiotics and anticancer drugs, are derived from natural products of bacteria. The enzyme complexes that produce these active ingredients have a modular design that makes them ideal tools ...
Cell & Microbiology
Mar 21, 2024
0
51
Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins. These biomolecules have different chemical groups on each end and side chain, and so, have the natural ability to form ...
Bio & Medicine
Jan 9, 2024
0
32
A highly active catalyst capable of synthesizing drug molecules within the body has been developed by RIKEN chemists. In mice, an anticancer drug assembled near tumors using the injected catalyst suppressed tumor growth.
Biochemistry
Dec 8, 2023
0
67
Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and ...
Biochemistry
Nov 13, 2023
0
201
Scientists at Tufts University School of Medicine have developed a genome-scale metabolic model or "subway map" of key metabolic activities of the bacterium that causes Lyme disease. Using this map, they have successfully ...
Cell & Microbiology
Oct 19, 2023
0
8
The potential to isolate and regulate the biodynamics of single cells is significant in drug design and screening. However, pre-existing experimental reports in single-cell drug screening must yet provide multiple-dose gradient ...
A research team co-led by chemists from City University of Hong Kong (CityU) recently discovered novel, highly effective anticancer agents with tridimensional structures, which have high anticancer activity, low toxicity ...
Biochemistry
Apr 6, 2023
0
18
Anticancer drugs are pivotal to cancer treatment, but their toxicity may not always be limited to cancer cells, resulting in harmful side-effects. To develop anticancer therapies that have fewer adverse effects on patients, ...
Biochemistry
Apr 3, 2023
0
11
Plants produce all types of curious chemicals. Some deter predators. Some smell wonderful. Some even have medicinal value. One of these hidden gems is (–)-jerantinine A (JA), a molecule with remarkable anticancer properties, ...
Biochemistry
Mar 23, 2023
0
26
