Breast cancer cells use force to open channels through tissue

Researching how cancers grow and spread has conventionally been done on two-dimensional, flat cultures of cells, which is very different to the three-dimensional structure of cells in the body. 3D cell cultures that incorporate ...

Basement membrane underpins tissue interactions in the skin

In a discovery that could pave the way for therapies that promote wound healing and alleviate skin diseases, RIKEN researchers have found that the network of molecules under the outermost layer of mouse skin, the skin epithelium, ...

New insights into early embryonic development

The majority of pregnancies that fail do so at a very early developmental stage, before the pregnancy is even detectable by tests. This critical stage, occurring about a week after fertilization, is when an embryo implants ...

Repairs in the basement membrane

Basement membrane (BM) is an evolutionarily ancient sheet-like scaffold that wraps around most animal tissues. BM protects and provides mechanical stiffness to tissues and regulates development, function, and repair. But ...

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