Beta amyloid
hideAmyloid beta (Aβ or Abeta) is a peptide of 39–43 amino acids that appear to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease. Aβ also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy. These plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as prions associated with protein misfolding diseases. Research on laboratory rats suggest that the two-molecule, soluble form of the peptide is a causative agent in the development of Alzheimer's and that the two-molecule form is the smallest synaptotoxic species of soluble amyloid beta oligomer
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News tagged with beta amyloid
Protein inhibitor helps rid brain of toxic tau protein
Medicine & Health / Neuroscience
Sep 29, 2009 |
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Inhibiting the protein Hsp70 rapidly reduces brain levels of tau, a protein associated with Alzheimer's disease when it builds up abnormally inside nerve cells affecting memory, neuroscientists at the University ...
Oxygen treatment hastens memory loss in Alzheimer's mice
Medicine & Health / Neuroscience
Aug 11, 2009 |
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A 65-year-old women goes into the hospital for routine hip surgery. Six months later, she develops memory loss and is later diagnosed with Alzheimer's Disease. Just a coincidence? Researchers at the University of South ...
Phase 3 Alzheimer's drug increases toxic beta amyloid in the brain -- but still provides benefits
Jul 15, 2009 |
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New insights into how a Phase III Alzheimer's drug might work were among the advances in potential therapies targeting two abnormal brain proteins - beta amyloid and phosphorylated tau - that were reported today at the Alzheimer's ...
Vaccine slows progression of skeletal muscle disorder
Medicine & Health / Neuroscience
May 13, 2009 |
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A potential vaccine for Alzheimer's disease also has been shown in mice to slow the weakening of muscles associated with inclusion body myositis, a disorder that affects the elderly.
Forgotten and lost - when proteins 'shut down' our brain
Biology /
Feb 17, 2009 |
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(PhysOrg.com) -- Which modules of the tau protein, in neurons of Alzheimer disease patients, may act in a destructive manner were investigated by researchers from the Max Planck Institute for Biophysical Chemistry ...
New Pathway is a Common Thread in Age-Related Neurodegenerative Diseases
Jan 29, 2009 |
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How are neurodegenerative diseases such as Alzheimer's initiated, and why is age the major risk factor? A recent study of a protein called MOCA (Modifier of Cell Adhesion), carried out at the Salk Institute ...
New study provides further evidence that apple juice can delay onset of Alzheimer's disease
Jan 22, 2009 |
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A growing body of evidence demonstrates that we can take steps to delay age-related cognitive decline, including in some cases that which accompanies Alzheimer's disease, according to a study published in the January 2009 ...
