News tagged with binding pocket
Discovery opens door for drugs to fight bird flu, other influenza epidemics
Aug 25, 2008 |
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Researchers at Rutgers University and The University of Texas at Austin have reported a discovery that could help scientists develop drugs to fight the much-feared bird flu and other virulent strains of influenza.
Search results for binding pocket
Mirror images united: Simultaneous binding of both enantiomers of a drug to an enzyme
Oct 29, 2009 |
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(PhysOrg.com) -- In the binding pockets of enzymes their natural binding partners fit exactly. The principle by which many pharmacological agents work also relies on the fact that these substances fit exactly into the pockets ...
Intrinsic changes in protein shape influence drug binding
Aug 19, 2009 |
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Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity. This shape-changing also ...
Discovery may lead to development of safer immunosuppressants
Mar 12, 2009 |
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Immunosuppressive treatment is necessary to prevent rejection of an organ after transplant and has great potential for treating chronic inflammatory diseases. However, currently available immunosuppressant drugs can pose ...
International team tracks clues to HIV
May 19, 2009 |
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Rice University's Andrew Barron and his group, working with labs in Italy, Germany and Greece, have identified specific molecules that could block the means by which the deadly virus spreads by taking away its ability to ...
How one virus uses mimicry to replicate successfully
Oct 31, 2007 |
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Both viruses and cancers subvert the growth-control machinery in a cell to serve their own needs. According to a new study, at least one virus uses mimicry to gain access to that machinery.
1930s drug slows tumor growth
Medicine & Health / Medications
Nov 06, 2009 |
4.7 / 5 (10) |
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Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease. The newest surprise discovered by researchers at the Johns ...
Researchers unveil vital key to cancer
Aug 06, 2008 |
4.7 / 5 (6) |
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University of Manchester scientists have uncovered the 3-D structure of Mps1 -- a protein that regulates the number of chromosomes during cell division and thus has an essential role in the prevention of cancer -- which will ...
Putting the squeeze on sperm DNA
Sep 30, 2009 |
4.8 / 5 (4) |
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(PhysOrg.com) -- In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have ...
Scientists find new structural motif in key enzymes is essential to prevent autoimmune disease
Jan 16, 2009 |
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Scientists from the Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation have found a specific mutation that leads to the development of severe autoimmune kidney disease in mice. The research ...
Molecule stops DNA replication in its tracks
Biology /
Oct 20, 2008 |
4 / 5 (3) |
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(PhysOrg.com) -- When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers ...
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