News tagged with binding site
Team pinpoints amino acid variation in immune response gene linked with ulcerative colitis
The association between the inflammatory bowel disease ulcerative colitis and a gene that makes certain cell surface proteins has been pinpointed to a variant amino acid in a crucial binding site that profoundly influences ...
Dec 15, 2011 |
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A good nose: Researchers decipher interaction of fragrances and olfactory receptors
Banana, mango or apricot - telling these smells apart is no problem for the human nose. How the olfactory organ distinguishes such similar smells has been uncovered by an interdisciplinary team of German researchers at the ...
Chemistry / Analytical Chemistry
Dec 13, 2011 |
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Researchers determine how antibody recognizes key sugars on HIV surface
HIV is coated in sugars that usually hide the virus from the immune system. Newly published research reveals how one broadly neutralizing HIV antibody actually uses part of the sugary cloak to help bind to the virus. The ...
Medicine & Health / HIV & AIDS
Nov 23, 2011 |
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Study finds a weak spot on deadly ebolavirus
Scientists from The Scripps Research Institute and the US Army's Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus ...
Nov 21, 2011 |
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Biologists create anti-HIV antibody that shows increased potency
Using highly potent antibodies isolated from HIV-positive people, researchers have recently begun to identify ways to broadly neutralize the many possible subtypes of HIV. Now, a team led by biologists at ...
Medicine & Health / HIV & AIDS
Oct 27, 2011 |
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How do protein binding sites stay dry in water?
In a report to be published soon in EPJE¹, researchers from the National University of the South in Bahía Blanca, Argentina studied the condition for model cavity and tunnel structures resembling the binding sites ...
Oct 21, 2011 |
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Key function of mutation in hereditary breast and ovarian cancer gene discovered
It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers ...
Sep 01, 2011 |
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Scientists map route for eliciting HIV-neutralizing antibodies
Researchers have traced in detail how certain powerful HIV neutralizing antibodies evolve, a finding that generates vital clues to guide the design of a preventive HIV vaccine, according to a study appearing in Science Ex ...
Medicine & Health / HIV & AIDS
Aug 11, 2011 |
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Scientists identify broad and potent HIV antibodies that mimic CD4 binding
In a finding that may be good news for scientists developing HIV vaccines and therapies, a team of researchers at The Rockefeller University and the Howard Hughes Medical Institute have found a way to investigate ...
Medicine & Health / HIV & AIDS
Jul 20, 2011 |
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Biologists reveal novel drug binding site in NMDA receptor subunit
Structural biologists at Cold Spring Harbor Laboratory (CSHL) have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly ...
Jun 16, 2011 |
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One drug, many targets: Finding molecular targets of an HIV drug used in cancer therapy
Researchers at the University of California, San Diego and Hunter College of the City University of New York (CUNY) have identified potential human molecular targets of the anti-HIV drug Nelfinavir, which may explain why ...
Medicine & Health / Medications
Apr 28, 2011 |
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Molecular simulations explain how enzymatic pumps transport calcium ions within muscle cells
The transport of ions is essential for the routine maintenance of the body. For this reason cells contain specialized enzymes that act as pumps that help ions to move around and pass through boundaries.
Feb 18, 2011 |
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Direct observation of carbon monoxide binding to metal-porphyrines
What makes carbon monoxide so toxic is that it blocks the binding site for oxygen in hemoglobin. This very mechanism, if better understood, could be used to implement sensors to warn against carbon monoxide. ...
Jan 10, 2011 |
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Can't live without it: The nicotine addiction
The first pull on a cigarette should send you into convulsions. The brain proteins that nicotine affects are nearly identical to a receptor protein on muscle cells that tells them to contract, but nicotine ...
Sep 23, 2010 |
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Team reveals all three structures of single transporter protein
A team of researchers from the Universities of Leeds, Oxford and Imperial College London have captured the 3D atomic models of a single transporter protein in each of its three main structural states, a goal ...
Apr 22, 2010 |
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