A powerful technique for tracking a protein's fleeting shape changes
Researchers at Weill Cornell Medicine have developed a powerful, new technique to generate "movies" of changing protein structures and speeds of up to 50 frames per second.
Researchers at Weill Cornell Medicine have developed a powerful, new technique to generate "movies" of changing protein structures and speeds of up to 50 frames per second.
Molecular & Computational biology
Apr 17, 2024
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Since the 1970s, modern antibiotic discovery has been experiencing a lull. Now the World Health Organization has declared the antimicrobial resistance crisis as one of the top 10 global public health threats.
Cell & Microbiology
Apr 8, 2024
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48
Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. Damage to this layer—lysosomal membrane permeabilization, or LMP for short—can ...
Cell & Microbiology
Apr 8, 2024
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Researchers at the Niels Bohr Institute, University of Copenhagen and University of Southern Denmark have recently published FreeDTS—a shared software package designed to model and study biological membranes at the mesoscale—the ...
Cell & Microbiology
Mar 22, 2024
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56
Candida albicans is a fungus that occurs naturally in the digestive tract of most people. However, the fungus is not always harmless. It can cause mild to severe infections throughout the body. A toxin, candidalysin, is involved ...
Cell & Microbiology
Mar 21, 2024
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70
Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed ...
Biochemistry
Mar 13, 2024
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A new solvatochromic probe could help shed light on the relationship between lipid membrane fluidity and various cellular functions, report scientists at Tokyo Institute of Technology and Kyushu University. Thanks to an innovative ...
Biochemistry
Mar 12, 2024
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Entropy is often associated with disorder and chaos, but in biology it is related to energy efficiency and is closely linked to metabolism, the set of chemical reactions that sustain life.
Bio & Medicine
Mar 6, 2024
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108
Drug development is currently an extremely long, expensive and inefficient process. Findings generated in a lab are often very hard to replicate once translated into animal models or in humans.
Biotechnology
Feb 26, 2024
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UAB researchers have produced the most complete map of the bacterial essential interactome, that is, how proteins combine and interact to perform functions essential for their survival. The research, published in the journal ...
Cell & Microbiology
Feb 22, 2024
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