News tagged with bisphosphonates
Study pinpoints genetic variation that raises a risk linked to bisphosphonates
Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class ...
Jan 27, 2012 |
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Study: Bone drug boosts breast cancer survival
(AP) -- Doctors were mostly hoping to prevent complications and relapses when they gave young women a medicine to keep their bones strong during breast cancer treatment. Seven years later, they found it did more than that: ...
Dec 09, 2011 |
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Oral bisphosphonate did not improve prognosis for patients with breast cancer
Results from a German study demonstrated no improvement in disease-free survival among patients with breast cancer who were treated with dose-dense chemotherapy and the bisphosphonate ibandronate.
Dec 07, 2011 |
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Clodronate appeared safe, modestly affected breast cancer disease events
A recently presented study revealed that the bisphosphonate clodronate had a low incidence of adverse events and toxicity among patients with breast cancer and may modestly reduce the incidence of distant metastases in postmenopausal ...
Dec 07, 2011 |
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Immediate bisphosphonate use with endocrine therapy increased survival in postmenopausal early breast cancer
The addition of zoledronic acid to adjuvant endocrine therapy increased bone mineral density and reduced the risk for disease recurrence among postmenopausal women with early hormone receptor-positive breast cancer, according ...
Dec 07, 2011 |
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Common bone drug may extend life of replacement joints
People who take bisphosphonates after joint replacement surgery are less likely to need a repeat operation, finds a new study published in the British Medical Journal today.
Medicine & Health / Medications
Dec 07, 2011 |
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Zoledronic acid reduces the recurrence of breast cancer in post-menopausal women
A trial investigating the use of zoledronic acid to aid chemotherapy for breast cancer has found a significant benefit for post-menopausal women, according to results presented at the 2011 European Multidisciplinary Cancer ...
Sep 25, 2011 |
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Low vitamin D levels are related to decreased response to osteoporosis medicine
Women with low bone density are seven times more likely to benefit from a bisphosphonate drug when their vitamin D blood levels are above recent recommendations from the Institute of Medicine (IOM) as adequate for bone health. ...
Jun 06, 2011 |
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Experts question whether preventive drugs are value for money
Experts today challenge the view that popular drugs to prevent disease - like statins and antihypertensives to prevent heart disease and stroke, or bisphosphonates to prevent fractures – represent value for money.
Medicine & Health / Medications
Apr 20, 2011 |
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Common bone drugs may reduce colon cancer risk
An international team of researchers has found that the use of bisphosphonates - drugs already taken by millions of healthy women to prevent bone-loss - for more than one year was associated with a 50 percent reduction in ...
Feb 16, 2011 |
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Journal of Dental Research releases large studies on osteonecrosis of the jaw
Osteonecrosis of the jaw (ONJ) is a debilitating bone condition that affects the jaws and occurs as a result of reduced local blood supply to the bone. The literature in this area has been severely limited since most investigations ...
Feb 11, 2011 |
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Bone drug Zometa flops in breast cancer study
(AP) -- Doctors are reporting a stunning setback for a promising new approach for fighting breast cancer.
Dec 09, 2010 |
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Taking a break from osteoporosis drugs can protect bones
Taking time off from certain osteoporosis drugs may be beneficial to bone health, according to a study conducted at Loyola University Health System. Researchers found that bone density remained stable for three years in patients ...
Nov 18, 2010 |
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FDA warns of fractures with osteoporosis drugs
(AP) -- Government health officials warned doctors and patients Wednesday about an increased risk of thigh fractures with a widely used group of bone-strengthening drugs.
Medicine & Health / Medications
Oct 13, 2010 |
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Long-term use of osteoporosis drugs associated with unusual fractures
(PhysOrg.com) -- Most hip fractures due to osteoporosis follow a pattern: the patient falls, and the bones around the hip joint shatter into pieces. But 2 to 3 years ago, orthopedic surgeons began seeing an increase in unusual ...
Medicine & Health / Medications
Sep 21, 2010 |
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Bisphosphonate
In pharmacology, bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digestion of bone by osteoclasts.
Osteoclasts also have constant turnover and normally destroy themselves by a process called cell suicide (apoptosis). Bisphosphonates encourage osteoclasts to undergo apoptosis.
The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta and other conditions that feature bone fragility.
For more information about Bisphosphonate, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
