News tagged with braf mutations
BRAF addiction of thyroid cancers makes them therapeutically vulnerable
Papillary carcinoma is the most common form of thyroid cancer. Approximately one quarter of these carcinomas have mutations in the BRAF gene. The prevalence of such mutations is even greater in high-grade carcinomas, particularly ...
Nov 21, 2011 |
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Combo therapies tested to overcome drug resistance in melanoma patients
About 50 to 60 percent of patients with melanoma have a mutation in the BRAF gene that drives the growth of their cancer. Most of these patients respond well to two novel agents being studied in clinical trials that inhibit ...
Aug 02, 2011 |
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BRAF inhibitor shows promising preclinical activity against melanoma
Preclinical findings recently published in Cancer Research, a journal of the American Association for Cancer Research, showed RG7204 (PLX4032) inhibited proliferation of tumor cell lines that expressed V600E-BRAF, a muta ...
Jun 15, 2010 |
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Scientists create mouse model of melanoma that generates hope for the use of targeted therapies
Researchers have developed a new mouse model that allows them to replicate normal pigment cells at the earliest stages of conversion to malignant skin cancer in humans. After testing the mouse with a combination of two drug ...
Mar 12, 2009 |
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Search results for braf mutations
Study uncovers mechanism by which melanoma drug accelerates secondary skin cancers
Patients with metastatic melanoma taking the recently approved drug vemurafenib (Zelboraf) responded well to the twice daily pill, but some of them developed a different, secondary skin cancer. Now, researchers at UCLA's ...
Jan 18, 2012 |
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First genome sequencing clinical trial for triple negative cancer points to new treatments
Initial results from an ongoing clinical trial, the first designed to examine the utility of whole-genome sequencing for triple negative breast cancer, were reported today during the CRTC-AACR San Antonio Breast Cancer Symposium.
Dec 08, 2011 |
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American Society of Clinical Oncology issues annual report on progress against cancer
The American Society of Clinical Oncology (ASCO) today released Clinical Cancer Advances 2011: ASCO's Annual Report on Progress Against Cancer, an independent review of the advances in cancer research that have had the greatest ...
Dec 05, 2011 |
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Researchers discover why new melanoma drug stops working
(Medical Xpress) -- Research led by investigators at Memorial Sloan-Kettering Cancer Center has identified a previously unknown mechanism of resistance to the newly approved melanoma drug, vemurafenib, an oral targeted therapy ...
Nov 24, 2011 |
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P Rex-1 protein key to melanoma metastasis
Researchers from UNC Lineberger Comprehensive Cancer Center are part of a team that has identified a protein, called P-Rex1, that is key to the movement of cells called melanoblasts. When these cells experience uncontrolled ...
Nov 22, 2011 |
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Panel of melanoma mutations opens door to new treatment possibilities
Researchers have developed a new genetic screening tool that will aid in the investigation of possible treatments for patients with melanoma and the unique genetic mutations that may accompany the disease, according to data ...
Nov 15, 2011 |
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New approaches may prevent certain side effects in BRAF mutation-positive melanoma
Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, ...
Nov 13, 2011 |
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Researchers find way to screen for broad range of cancer-causing genetic changes
Researchers in the United States have shown, for the first time, that it is possible to screen cancer patients for a broad range of cancer-causing genetic mutations as part of normal clinical practice. By identifying patients' ...
Nov 09, 2011 |
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Improved method for detecting mutant DNAs
Molecular DNA testing methods offer clinicians powerful tools that serve to confirm or identify disease diagnoses. High sensitivity and high specificity, however, are frequently a challenge to achieve with these methods. ...
Oct 11, 2011 |
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US approves new drug against skin cancer
A breakthrough drug that could extend survival in some patients with advanced skin cancer was approved on Wednesday by US regulators, offering the first new treatment for melanoma in 13 years.
Aug 17, 2011 |
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