News tagged with brca2
Women with certain type of ovarian cancer and BRCA gene mutation have improved survival at 5 years
Among women with invasive epithelial ovarian cancer, patients having a germline (gene change in a reproductive cell that could be passed to offspring) mutation in the BRCA1 or BRCA2 genes was associated with improved 5-year ...
Jan 24, 2012 |
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Study finds first major genetic mutation associated with hereditary prostate cancer risk
After a 20-year quest to find a genetic driver for prostate cancer that strikes men at younger ages and runs in families, researchers have identified a rare, inherited mutation linked to a significantly higher risk of the ...
Jan 11, 2012 |
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Gene inheritance patterns influence age of diagnosis in BRCA families
Women who inherit the cancer genes BRCA1 or BRCA2 from their paternal lineage may get a diagnosis a decade earlier than those women who carry the cancer genes from their mother and her ancestors, according to a new study ...
Dec 12, 2011 |
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Breast cancer type linked to paternal cancer
The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's ...
Nov 28, 2011 |
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Ovarian cancer patients survive longer with BRCA2 mutated in tumors
Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute ...
Oct 11, 2011 |
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BRCA2 genetic mutation associated with improved survival, chemotherapy response in ovarian cancer
Among women with a certain type of high-grade ovarian cancer, having BRCA2 genetic mutations, but not BRCA1, was associated with improved overall survival and improved response to chemotherapy, compared to women with BRCA ...
Oct 11, 2011 |
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Mismatch between cancer genetics counseling and testing guidelines and physician practices
A new analysis has found that many doctors report that they do not appropriately offer breast and ovarian cancer counseling and testing services to their female patients. Published early online in CANCER, a peer-reviewed journa ...
Jul 25, 2011 |
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Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal
Women with the BRCA1 or BRCA2 gene mutations, which are linked to a very high risk of breast and ovarian cancer, can safely take hormone-replacement therapy (HRT) to mitigate menopausal symptoms after surgical removal of ...
Jun 01, 2011 |
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BRCA2 mutations associated with improved survival for ovarian cancer
Women with ovarian cancer who have the BRCA2 gene mutation are more likely to survive the malignancy than women with the BRCA1 mutation, or women without either mutation.
Apr 04, 2011 |
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DNA and the 'magic rings' trick
(PhysOrg.com) -- A new study from UC Davis shows how, like a conjuring trick with interlocking rings, two interlocked pieces of DNA are separated after DNA is copied or repaired. The finding was published online Oct. 10 in ...
Oct 11, 2010 |
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Coping with genetic predisposition to cancer
Kelly Metcalfe, a professor at the Bloomberg Faculty of Nursing, focuses her research on a unique population of women faced with some really tough decisions and helps them reach satisfactory conclusions.
Sep 29, 2010 |
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First purification of cancer gene, BRCA2, studied by UNC scientists
Scientists at the University of North Carolina at Chapel Hill were among co-authors of a study that described the first isolation and purification of the BRCA2 protein which is produced by a gene whose loss ...
Sep 15, 2010 |
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Protein made by breast cancer gene purified
A key step in understanding the origins of familial breast cancer has been made by two teams of scientists at the University of California, Davis. The researchers have purified, for the first time, the protein produced by ...
Aug 22, 2010 |
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New drug reduces tumor size in women with advanced hereditary ovarian or breast cancer
Understanding the underlying genetic weakness of certain types of cancer may lead to targeted therapy and provide the key to effective treatment, a new study suggests. An international consortium of researchers has shown ...
Aug 12, 2010 |
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Revolutionary therapy slows tumor growth in advanced breast cancer
The new drug olaparib has antitumour activity in carriers of the BRCA1 or BRCA2 gene mutations who have advanced ovarian or breast cancer, according to the findings of two proof-of-concept trials. Together with previous findings, ...
Jul 05, 2010 |
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BRCA2
More reference expression data
BRCA2 (Breast Cancer Type 2 susceptibility protein) is a protein that in humans is encoded by the BRCA2 gene. BRCA2 belongs to the tumor suppressor gene family and the protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks.
The BRCA2 gene is located on the long (q) arm of chromosome 13 at position 12.3 (13q12.3), from base pair 31,787,616 to base pair 31,871,804.
For more information about BRCA2, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
