Cancer stem cell
hideCancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. These cells are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are proposed to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for sufferers of metastatic disease.
Existing cancer treatments were mostly developed on animal models, where therapies able to promote tumor shrinkage were deemed effective. However, animals could not provide a complete model of human disease. In particular, in mice, whose life spans do not exceed two years, tumor relapse is exceptionally difficult to study.
The efficacy of cancer treatments are, in the initial stages of testing, often measured by the fraction of tumor mass they kill off (fractional kill). As CSCs would form a very small proportion of the tumor, this may not necessarily select for drugs that act specifically on the stem cells. The theory suggests that conventional chemotherapies kill differentiated or differentiating cells, which form the bulk of the tumor but are unable to generate new cells. A population of CSCs, which gave rise to it, could remain untouched and cause a relapse of the disease.
For more information about Cancer stem cell, read the full article at
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News tagged with cancer stem
Potential new 'twist' in breast cancer detection
Dec 04, 2009 |
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Working with mice, scientists at Johns Hopkins publishing in the December issue of Neoplasia have shown that a protein made by a gene called "Twist" may be the proverbial red flag that can accurately distinguish stem cells ...
Australian bid to 'regrow' breasts after cancer surgery
Nov 12, 2009 |
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Australian scientists said Thursday they were to trial a revolutionary treatment which would allow women to regrow their breasts after cancer surgery.
Researchers find triggers in cells' transition from colitis to cancer
Oct 12, 2009 |
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(PhysOrg.com) -- University of Florida researchers have grown tumors in mice using cells from inflamed but noncancerous colon tissue taken from human patients, a finding that sheds new light on colon cancer ...
Aspirin protection for Lynch syndrome
Sep 28, 2009 |
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(PhysOrg.com) -- A daily dose of aspirin can prevent the occurrence of cancer in people with a genetic predisposition towards Lynch syndrome, a Newcastle University scientist has told Europe’s largest cancer congress. Lynch ...
Diabetes drug kills cancer stem cells in combination treatment in mice
Sep 14, 2009 |
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In a one-two punch, a familiar diabetes drug reduced tumors faster and prolonged remission in mice longer than chemotherapy alone by targeting cancer stem cells, Harvard Medical School researchers reported in the September ...
Scientists find common trigger in cancer and normal stem cell reproduction
Aug 06, 2009 |
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Researchers at Stanford University School of Medicine have discovered, for the first time, a common molecular pathway that is used by both normal stem cells and cancer stem cells when they reproduce themselves.
Stem cell 'daughters' lead to breast cancer
Aug 02, 2009 |
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Walter and Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations ...
Researchers develop model that may help identify cancer stem cells
Jun 16, 2009 |
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Researchers at UCLA's Jonsson Comprehensive Cancer Center, on a quest to find lung cancer stem cells, have developed a unique model to allow further investigation into the cells that many believe may be at the root of all ...
A lethal cancer knocked down by one-two drug punch
Jun 07, 2009 |
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In the battle against cancer, allies can come from unexpected sources. Research at The Jackson Laboratory has yielded a new approach to treating leukemia, one that targets leukemia-proliferating cells with drugs that are ...
Study points toward relationship between cancer stem cells and prognosis in primary breast cancer
May 15, 2009 |
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Breast cancer patients who received chemotherapy prior to surgery had heightened levels of cancer-initiating stem cells in their bone marrow, and the level of such cells correlated to a tumor's lymph node involvement, according ...
Scientists discover source of cancer stem cells' resistance to radiation
Feb 04, 2009 |
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Much to the dismay of patients and physicians, cancer stem cells — tiny powerhouses that generate and maintain tumor growth in many types of cancers — are relatively resistant to the ionizing radiation often used as therapy ...
Engineered virus targets and kills apparent cancer stem cells in neuroblastoma
Jan 21, 2009 |
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After identifying an apparent population of cancer stem cells for neuroblastoma, researchers successfully used a reprogrammed herpes virus to block tumor formation in mice by targeting and killing the cells.
Scientists can now differentiate between healthy cells and cancer cells
Biology /
Jan 05, 2009 |
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One of the current handicaps of cancer treatments is the difficulty of aiming these treatments at destroying malignant cells without killing healthy cells in the process. But a new study by McMaster University researchers ...
Molecular marker identifies normal stem cells as intestinal tumor source
Dec 17, 2008 |
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Scientists at St. Jude Children's Research Hospital have answered a central question in cancer biology: whether normal stem cells can give rise to tumors. Stem cells are immature cells that can renew themselves and give rise ...
Therapy may block expansion of breast cancer cells
Nov 05, 2008 |
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Breast cancer stem cells are known to be involved in therapy resistance and the recurrence of cancerous tumors. A new study appearing in Clinical and Translational Science shows the mechanisms governing stem cell expansion in bre ...
