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Cancer
hideCancer (medical term: malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, and do not invade or metastasize. Most cancers form a tumor but some, like leukemia, do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is oncology.
Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all human deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.
Nearly all cancers are caused by abnormalities in the genetic material of the transformed cells. These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers are usually affected by complex interactions between carcinogens and the host's genome. New aspects of the genetics of cancer pathogenesis, such as DNA methylation, and microRNAs are increasingly recognized as important.
Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system.
Diagnosis usually requires the histologic examination of a tissue biopsy specimen by a pathologist, although the initial indication of malignancy can be symptoms or radiographic imaging abnormalities. Most cancers can be treated and some cured, depending on the specific type, location, and stage. Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. As research develops, treatments are becoming more specific for different varieties of cancer. There has been significant progress in the development of targeted therapy drugs that act specifically on detectable molecular abnormalities in certain tumors, and which minimize damage to normal cells. The prognosis of cancer patients is most influenced by the type of cancer, as well as the stage, or extent of the disease. In addition, histologic grading and the presence of specific molecular markers can also be useful in establishing prognosis, as well as in determining individual treatments.
For more information about Cancer, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with cancer
Scientists crack gene code of common cancers
Dec 17, 2009 |
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Two common forms of cancer have been genetically mapped for the first time, British scientists announced, in a major breakthrough in understanding the diseases.
Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
Dec 18, 2009 |
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A New York Medical College physician who specializes in restoring or preserving fertility in female cancer patients has discovered a possible link between the presence of breast cancer genes and infertility.
Lung cancer and melanoma laid bare: First comprehensive analysis of two cancer genomes
Dec 16, 2009 |
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Research teams led by the Wellcome Trust Sanger Institute announce the first comprehensive analyses of cancer genomes. All cancers are caused by mutations in the DNA of cancer cells which are acquired during a person's lifetime. ...
Study reveals chemo's toxicity to brain, possible treatment
Dec 17, 2009 |
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Researchers have developed a novel animal model showing that four commonly used chemotherapy drugs disrupt the birth of new brain cells, and that the condition could be partially reversed with the growth factor IGF-1.
Pores finding reveals targets for cancer and degenerative disease
Dec 18, 2009 |
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Walter and Eliza Hall Institute scientists have identified a key step in the biological process of programmed cell death, also called apoptosis.
Scientists use nanosensors for first time to measure cancer biomarkers in blood
Nanotechnology / Bio & Medicine
Dec 13, 2009 |
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A team led by Yale University researchers has used nanosensors to measure cancer biomarkers in whole blood for the first time. Their findings, which appear December 13 in the advanced online publication of ...
Scientists use DNA sequencing to attack lung cancer
Dec 16, 2009 |
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Aided by next-generation DNA sequencing technology, an international team of researchers has gained insights into how more than 60 carcinogens associated with cigarette smoke bind to and chemically modify human DNA, ultimately ...
Stem-cell activators switch function, repress mature cells
Dec 16, 2009 |
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In a developing animal, stem cells proliferate and differentiate to form the organs needed for life. A new study shows how a crucial step in this process happens and how a reversal of that step contributes to cancer.
Smoking and Drinking Linked to Bowel Cancer: Know Your Risks
Dec 17, 2009 |
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(PhysOrg.com) -- Besides delectable dishes that help us pack on the pounds during the holiday season, many people also let loose with a bottle of wine or a pack of cigarettes. Richard Rood, MD, says moderation ...
Plastics component affects intestine: study
Dec 14, 2009 |
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The chemical Bisphenol A used in plastic containers and drinks cans has been shown for the first time to affect the functioning of the intestines, according to a French study published Monday.
Nanoprobes hit targets in tumors, could lessen chemo side effects
Nanotechnology / Bio & Medicine
Dec 14, 2009 |
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(PhysOrg.com) -- Tiny nanoprobes have shown to be effective in delivering cancer drugs more directly to tumor cells - mitigating the damage to nearby healthy cells - and Purdue University research has shown that the nanoprobes ...
Researchers identify possible imaging method to stratify breast cancer without biopsy
Dec 17, 2009 |
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Scientists from the Kimmel Cancer Center at Jefferson have discovered a possible way for malignant breast tumors to be identified, without the need for a biopsy. The findings were published online ahead of print in the Journal of ...
Tracking new cancer-killing particles with MRI
Nanotechnology / Nanomaterials
Dec 14, 2009 |
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Researchers at Rice University and Baylor College of Medicine (BCM) have created a single nanoparticle that can be tracked in real time with MRI as it homes in on cancer cells, tags them with a fluorescent ...
Scientists Uncover Protective Mechanism Against Liver Cancer
Dec 14, 2009 |
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(PhysOrg.com) -- A team of scientists from the UC San Diego School of Medicine and Osaka University in Japan have identified a protein switch that helps prevent liver damage, including inflammation, fibrosis and cancer. The ...
New protein key for cell proliferation identified
Dec 14, 2009 |
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(PhysOrg.com) -- Researchers at McGill University have identified a protein that plays a key role in cell proliferation and is likely to promote cancer development. The work may lead to the development of new diagnostic tools ...
