Related topics: cancer cells , cells , tumor cells , proceedings of the national academy of sciences , patients
Cancer
hideCancer (medical term: malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, and do not invade or metastasize. Most cancers form a tumor but some, like leukemia, do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is oncology.
Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all human deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.
Nearly all cancers are caused by abnormalities in the genetic material of the transformed cells. These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers are usually affected by complex interactions between carcinogens and the host's genome. New aspects of the genetics of cancer pathogenesis, such as DNA methylation, and microRNAs are increasingly recognized as important.
Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system.
Diagnosis usually requires the histologic examination of a tissue biopsy specimen by a pathologist, although the initial indication of malignancy can be symptoms or radiographic imaging abnormalities. Most cancers can be treated and some cured, depending on the specific type, location, and stage. Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. As research develops, treatments are becoming more specific for different varieties of cancer. There has been significant progress in the development of targeted therapy drugs that act specifically on detectable molecular abnormalities in certain tumors, and which minimize damage to normal cells. The prognosis of cancer patients is most influenced by the type of cancer, as well as the stage, or extent of the disease. In addition, histologic grading and the presence of specific molecular markers can also be useful in establishing prognosis, as well as in determining individual treatments.
For more information about Cancer, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with cancer
Implant-based cancer vaccine is first to eliminate tumors in mice
Nov 25, 2009 |
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(PhysOrg.com) -- A cancer vaccine carried into the body on a carefully engineered, fingernail-sized implant is the first to successfully eliminate tumors in mammals, scientists report this week in the journal ...
Nanoparticles used in common household items caused genetic damage in mice
Nanotechnology / Bio & Medicine
Nov 16, 2009 |
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Titanium dioxide (TiO2) nanoparticles, found in everything from cosmetics to sunscreen to paint to vitamins, caused systemic genetic damage in mice, according to a comprehensive study conducted by researchers at UCLA's Jonsson ...
Study shows that some malignant tumors can be shut down after all
Nov 09, 2009 |
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Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations within ...
Findings show nanomedicine promising for treating spinal cord injuries
Nanotechnology / Bio & Medicine
Nov 08, 2009 |
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(PhysOrg.com) -- Researchers at Purdue University have discovered a new approach for repairing damaged nerve fibers in spinal cord injuries using nano-spheres that could be injected into the blood shortly ...
1930s drug slows tumor growth
Medicine & Health / Medications
Nov 06, 2009 |
4.7 / 5 (10) |
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Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease. The newest surprise discovered by researchers at the Johns ...
Nanoparticles for gene therapy improve
Nanotechnology / Bio & Medicine
Nov 06, 2009 |
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(PhysOrg.com) -- About five years ago, Professor Janet Sawicki at the Lankenau Institute in Pennsylvania read an article about nanoparticles developed by MIT's Robert Langer for gene therapy, the insertion ...
Newly Discovered Fat Molecule: An Undersea Killer with an Upside
Nov 05, 2009 |
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(PhysOrg.com) -- A chemical culprit responsible for the rapid, mysterious death of phytoplankton in the North Atlantic Ocean has been found by collaborating scientists at Rutgers University and the Woods Hole ...
Two-In-One Punch Knocks Out Drug Resistant Cancer Cells
Nanotechnology / Bio & Medicine
Nov 04, 2009 |
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(PhysOrg.com) -- Cancer cells, like bacteria, can develop resistance to drug therapy, leading to relapse of disease. One approach showing promise in overcoming multidrug resistance in tumors is to combine two different anticancer ...
Researchers use drug-radiation combo to eradicate lung cancer
Oct 29, 2009 |
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Researchers at UT Southwestern Medical Center have eliminated non-small cell lung (NSCL) cancer in mice by using an investigative drug called BEZ235 in combination with low-dose radiation.
Scientists discover gene that 'cancer-proofs' rodent's cells
Oct 26, 2009 |
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(PhysOrg.com) -- Despite a 30-year lifespan that gives ample time for cells to grow cancerous, a small rodent species called a naked mole rat has never been found with tumors of any kind—and now biologists ...
Study shows how carbon nanotubes can affect lining of the lungs
Nanotechnology / Bio & Medicine
Oct 25, 2009 |
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(PhysOrg.com) -- Carbon nanotubes are being considered for use in everything from sports equipment to medical applications, but a great deal remains unknown about whether these materials cause respiratory ...
Research sheds light on workings of anti-cancer drug
Chemistry / Analytical Chemistry
Nov 26, 2009 |
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(PhysOrg.com) -- The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. ...
Serotonin Made in Breast Cancer Cells, Researchers Show
Nov 24, 2009 |
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(PhysOrg.com) -- Researchers at the University of Cincinnati have documented that the brain hormone serotonin is made in human breast cancer cells and functions abnormally, contributing to malignant growth.
Tissue tension regulates tumor progression
Nov 23, 2009 |
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(PhysOrg.com) -- UCSF scientists have shown for the first time that the rigidity of a tissue can induce cancer. The research team identified an enzyme that is crucial for regulating tissue stiffness and demonstrated that ...
Sponges against cancer
Nov 20, 2009 |
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Deep under the sea, there's a battle of life and death going on, with no holds barred. Sponges and other marine animals which cannot move around might seem to be defenceless against predators. Yet nothing is further from ...
