Cell migration
hideCell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Errors during this process have serious consequences, including mental retardation, vascular disease, tumor formation and metastasis. An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling , for example, invasive tumour cells. Cells often migrate in response to, and towards, specific external signals, a process called chemotaxis.
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News tagged with cell migration
Finding could lead to advance in nano-surgery
Nov 25, 2008 |
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(PhysOrg.com) -- One of the problems with laser surgery is that the heat produced can damage tissue, and even lead to cell death. Attempts are being made to replace laser surgery with non-thermal plasma interaction, ...
Carbohydrate acts as tumor suppressor
Jul 06, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These ...
Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis
Nov 25, 2009 |
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Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers ...
'Second hit' pushes noninvasive breast cancer towards deadly metastasis
Sep 08, 2009 |
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A new study identifies a molecule that acts cooperatively with a well known oncoprotein to drive progression of noninvasive breast cancer to metastatic, life-threatening disease. The research findings, published by Cell Press ...
Researchers describe function of key protein in cancer spread
May 21, 2009 |
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Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread ...
Reactive oxygen's role in metastasis
Sep 16, 2009 |
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Researchers at the Burnham Institute for Medical Research have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in ...
Researchers identify key factor that stimulates brain cancer cells to spread
Aug 18, 2009 |
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Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM). In a move toward ...
Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer
Feb 23, 2009 |
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Tumors that are about to progress and metastasize go through a process also seen in normal embryonic development, known as the epithelial to mesenchymal transition (EMT). Tumor cells revert to a less-differentiated state, ...
Scientists find new structural motif in key enzymes is essential to prevent autoimmune disease
Jan 16, 2009 |
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Scientists from the Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation have found a specific mutation that leads to the development of severe autoimmune kidney disease in mice. The research ...
Signaling between protein, growth factor is critical for coordinated cell migration
Nov 10, 2008 |
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The mysterious process that orchestrates cells to move in unison to form human and animal embryos, heal wounds, and even spread cancer depends on interaction between two well-known genetic signaling pathways, two University ...
Proepithelin encourages cell growth and migration in prostate cancer
Feb 26, 2009 |
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Researchers from Thomas Jefferson University have identified a protein that appears to play a significant role in the growth and migration of prostate cancer cells, especially androgen-independent prostate cancer cells. The ...
Is transforming growth factor-beta involved in intestinal wound healing?
Mar 30, 2009 |
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Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation ...
Surprise discovery made in cancer research
Dec 01, 2008 |
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One of the defining characteristics of cancer cells is that they systematically prevent programmed cell death (apoptosis), with which the body guards itself against the proliferation of defective cells. In ...
