A new RNA editing tool could enhance cancer treatment
Cell therapies for cancer can be potentially enhanced using a CRISPR RNA-editing platform, according to a new study published Feb. 21 in Cell.
Cell therapies for cancer can be potentially enhanced using a CRISPR RNA-editing platform, according to a new study published Feb. 21 in Cell.
Cell & Microbiology
Feb 21, 2024
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Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.
Biotechnology
Feb 1, 2024
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112
Researchers at Karolinska Institutet in Sweden have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new ...
Cell & Microbiology
Jan 18, 2024
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83
Bile ducts are pathways that carry hepatocyte-produced bile from the liver to the small intestine. In the human fetal liver, bile ducts are formed from bile duct epithelial cells surrounding the portal vein, and hepatocytes ...
Cell & Microbiology
Jan 9, 2024
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Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable ...
Biochemistry
Dec 8, 2023
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8
Depression, obesity or chronic pain—all of these disorders can be triggered or promoted by stress. In two publications, researchers at TU Darmstadt show new ways of treating stress-related diseases.
Biochemistry
Nov 10, 2023
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An ideal medicine for one person may prove ineffective or harmful for someone else, and predicting who could benefit from a given drug has been difficult. Now, an international team led by neuroscientist Kirill Martemyanov, ...
Cell & Microbiology
Oct 31, 2023
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119
Engineers at the University of California San Diego have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles ...
Bio & Medicine
Oct 30, 2023
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Japanese scientist Kikunae Ikeda first proposed umami as a basic taste—in addition to sweet, sour, salty and bitter—in the early 1900s. About eight decades later, the scientific community officially agreed with him.
Cell & Microbiology
Oct 5, 2023
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393
All over the world, huge quantities of crop protection agents are sprayed to control potato blight (Phytophthora infestans). The mechanisms of resistance of potatoes need to be better understood to make growing this crop ...
Molecular & Computational biology
Sep 11, 2023
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1
In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach. A molecule which binds to a receptor is called a "ligand," and may be a peptide (such as a neurotransmitter), a hormone, a pharmaceutical drug, or a toxin, and when such binding occurs, the receptor undergoes a conformational change which ordinarily initiates a cellular response. However, some ligands merely block receptors without inducing any response (e.g. antagonists). Ligand-induced changes in receptors result in physiological changes which constitute the biological activity of the ligands.
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