A recent UCLA study demonstrates a new process for screening T cells, part of the body's natural defenses, for characteristics vital to the success of cell-based treatments. The method filters T cells based on the receptor ...
Bio & Medicine
Apr 15, 2024
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46
Caterpillars have the ability to consume copious amounts of plant materials in a short time. Caterpillars use their antennae to scan their surroundings in order to eat safely in a hostile environment. Researchers of Wageningen ...
Plants & Animals
Apr 10, 2024
0
271
A team of bioengineers at Instituto Gulbenkian de Ciência, in Portugal, has found that inactivating the Tgfbr1 gene in mouse embryos results in altered development in the trunk to tail region.
Cell therapies for cancer can be potentially enhanced using a CRISPR RNA-editing platform, according to a new study published Feb. 21 in Cell.
Cell & Microbiology
Feb 21, 2024
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70
Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.
Biotechnology
Feb 1, 2024
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112
Researchers at Karolinska Institutet in Sweden have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new ...
Cell & Microbiology
Jan 18, 2024
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83
Bile ducts are pathways that carry hepatocyte-produced bile from the liver to the small intestine. In the human fetal liver, bile ducts are formed from bile duct epithelial cells surrounding the portal vein, and hepatocytes ...
Cell & Microbiology
Jan 9, 2024
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1
Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable ...
Biochemistry
Dec 8, 2023
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8
Depression, obesity or chronic pain—all of these disorders can be triggered or promoted by stress. In two publications, researchers at TU Darmstadt show new ways of treating stress-related diseases.
Biochemistry
Nov 10, 2023
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53
An ideal medicine for one person may prove ineffective or harmful for someone else, and predicting who could benefit from a given drug has been difficult. Now, an international team led by neuroscientist Kirill Martemyanov, ...
Cell & Microbiology
Oct 31, 2023
0
119
In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach. A molecule which binds to a receptor is called a "ligand," and may be a peptide (such as a neurotransmitter), a hormone, a pharmaceutical drug, or a toxin, and when such binding occurs, the receptor undergoes a conformational change which ordinarily initiates a cellular response. However, some ligands merely block receptors without inducing any response (e.g. antagonists). Ligand-induced changes in receptors result in physiological changes which constitute the biological activity of the ligands.
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