News tagged with checkpoint mechanisms
Scripps research team unravels new cellular repair mechanism
Biology /
Aug 06, 2008 |
5 / 5 (4) |
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A Scripps Research team has unraveled a new biochemical pathway that triggers a critical repair response to correct errors in the DNA replication process that could otherwise lead to harmful or fatal mutations in cells. Though ...
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Researchers illuminate mechanisms that regulate DNA damage control and replication
Biology /
Jan 05, 2009 |
3 / 5 (1) |
0
Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating ...
Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
Jul 01, 2008 |
4.6 / 5 (9) |
2
Each day, a staggering number of cells perform a feat that still amazes researchers with its complexity: they divide to produce perfect replicas of each other. The process is called mitosis, and an inability to control it ...
Chemotherapy resistance: Checkpoint protein provides armor against cancer drugs
Aug 27, 2009 |
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Cell cycle checkpoints act like molecular tripwires for damaged cells, forcing them to pause and take stock. Leave the tripwire in place for too long, though, and cancer cells will press on regardless, making ...
New insight into cell division
Oct 27, 2006 |
4.2 / 5 (15) |
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When cells divide, control mechanisms ensure that the genetic material, in other words the chromosomes, is correctly distributed to the daughter cells. Researchers at the Max Planck Institute for Molecular ...
Chromatin remodeling complex connected to DNA damage control
Biology /
Aug 09, 2007 |
2.5 / 5 (2) |
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When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report ...
Biologists discover link between CGG repeats in DNA and neurological disorders
Biology /
Jan 11, 2009 |
5 / 5 (2) |
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Researchers have long known that some repetitive DNA sequences can make human chromosomes "fragile," i.e. appearing constricted or even broken during cell divisions. Scientists at Tufts University have found that one such ...
Researchers find how a common genetic mutation makes cancer radiation resistant
Jun 10, 2009 |
5 / 5 (1) |
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(PhysOrg.com) -- Many cancerous tumors possess a genetic mutation that disables a tumor suppressor called PTEN. Now researchers at Washington University School of Medicine in St. Louis have shown why inactivation of PTEN ...
A potential approach to treatment of hepatitis B virus infection
Sep 10, 2008 |
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Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. There are two branches in the checkpoint response pathway—ataxia telangiectasia-mutated (ATM) ...
Researchers discover mechanism of cell type-specific signaling in tumor development
Apr 07, 2009 |
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Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development — factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from ...
Cellular discovery may lead to targeted treatment for rare form of anemia
Mar 15, 2009 |
5 / 5 (2) |
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University of Cincinnati (UC) researchers have identified the specific biological mechanisms believed to lead to a rare and incurable blood disease known as Diamond Blackfan anemia (DBA). Scientists say with further investigation, ...
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