News tagged with checkpoint proteins
Study supports DNA repair-blocker research in cancer therapy
Aug 17, 2009 |
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Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing ...
Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
Jul 01, 2008 |
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Each day, a staggering number of cells perform a feat that still amazes researchers with its complexity: they divide to produce perfect replicas of each other. The process is called mitosis, and an inability to control it ...
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Researchers illuminate mechanisms that regulate DNA damage control and replication
Biology /
Jan 05, 2009 |
3 / 5 (1) |
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Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating ...
A new cellular pathway linked to cancer is identified
Jul 24, 2008 |
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In the life of a cell, the response to DNA damage determines whether the cell is fated to pause and repair itself, commit suicide, or grow uncontrollably, a route leading to cancer. In a new study, published in the July 25th ...
Researchers shed light on how tumor cells form
Jun 21, 2006 |
5 / 5 (6) |
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MIT cancer researchers have discovered a process that may explain how some tumor cells form, a discovery that could one day lead to new therapies that prevent defective cells from growing and spreading.
DNA damage response confers a barrier for viral tumorigenesis
Sep 28, 2007 |
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Kaposi’s sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi’s sarcoma (KS). KSHV infection is endemic in sub-Saharan Africa where KS is nowadays the most common malignancy, due to widespread ...
Chromatin remodeling complex connected to DNA damage control
Biology /
Aug 09, 2007 |
2.5 / 5 (2) |
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When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report ...
New insight into cell division
Oct 27, 2006 |
4.2 / 5 (15) |
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When cells divide, control mechanisms ensure that the genetic material, in other words the chromosomes, is correctly distributed to the daughter cells. Researchers at the Max Planck Institute for Molecular ...
Chemotherapy resistance: Checkpoint protein provides armor against cancer drugs
Aug 27, 2009 |
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Cell cycle checkpoints act like molecular tripwires for damaged cells, forcing them to pause and take stock. Leave the tripwire in place for too long, though, and cancer cells will press on regardless, making ...
Scripps research team unravels new cellular repair mechanism
Biology /
Aug 06, 2008 |
5 / 5 (4) |
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A Scripps Research team has unraveled a new biochemical pathway that triggers a critical repair response to correct errors in the DNA replication process that could otherwise lead to harmful or fatal mutations in cells. Though ...
Biologists discover link between CGG repeats in DNA and neurological disorders
Biology /
Jan 11, 2009 |
5 / 5 (2) |
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Researchers have long known that some repetitive DNA sequences can make human chromosomes "fragile," i.e. appearing constricted or even broken during cell divisions. Scientists at Tufts University have found that one such ...
Scientists discover remarkable editing system for protein production
Jan 03, 2008 |
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Even small mistakes made by cells during protein production can have profound disease effects, but the processes cells use to correct mistakes have been challenging to decipher. Recent work by scientists at The Scripps Research ...
List of search results for checkpoint proteins
