News tagged with cleavage site
How proteins talk to each other: Caspase-3 cleaves in unforeseen ways
Investigators at Burnham Institute for Medical Research have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced proteomic technique called ...
Sep 21, 2009 |
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New insights into how SARS pathogen infects host
(PhysOrg.com) -- When Severe Acute Respiratory Syndrome (SARS) first appeared in 2003, international cooperation helped contain the virulent coronavirus, which caused respiratory illness in more than 8,000 ...
Apr 14, 2009 |
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Scientists illuminate cancer cells' survival strategy
A team led by scientists at The Scripps Research Institute has discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs. The finding could lead to drugs that could inhibit ...
Jan 26, 2012 |
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H5N1 virus targets pulmonary endothelial cells
The H5N1 virus has killed roughly 60 percent of humans infected, a mortality rate which is orders of magnitude higher than that of seasonal influenza virus. Many victims of the former fall heir to acute respiratory distress ...
Jan 20, 2012 |
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Innovative approach successfully maps susceptibility to type 2 diabetes
Research carried out at the Hebrew University of Jerusalem has provided the first proof of molecular risk factors leading to type 2 diabetes, providing an “early warning” sign that could lead to new approaches ...
Dec 28, 2011 |
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Greenhouse gas-producing enzyme may yield insights into earliest oxygen-breathing ancestor evolution
Every year, nitrogen-metabolizing bacteria in the soil and seas churn out more than ten billion kilograms of nitrous oxide (N2O) gas as they respire in these oxygen-deficient environments.
Mar 07, 2011 |
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Camera on Curiosity's arm will magnify clues in rocks
NASA's next Mars rover, Curiosity, will wield an arm-mounted magnifying camera similar to one on the Mars Rover Opportunity, which promptly demonstrated its importance for reading environmental history from ...
Space & Earth / Space Exploration
Nov 17, 2010 |
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Identifying molecular guardian of cell's RNA
When most genes are transcribed, the nascent RNAs they produce are not quite ready to be translated into proteins - they have to be processed first. One of those processes is called splicing, a mechanism by ...
Oct 25, 2010 |
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Fight against cancer gets help from salmonella bacteria
Scientists have uncovered a novel mechanism by which Salmonella bacteria infect humans and say the discovery could potentially be exploited to kill cancerous cells.
Oct 25, 2010 |
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Promising new 'antigene' therapy
Antigene therapy is a promising new treatment strategy that uses a DNA-based drug to pinpoint light energy to a target gene shutting down its activity. A review article published online ahead of print in Oligonucleotides, a peer ...
Oct 21, 2010 |
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Protease associated with damage after stroke implicated in Huntington's toxicity
A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July ...
Medicine & Health / Neuroscience
Jul 28, 2010 |
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Understanding the APJ Receptor Binding Site
(PhysOrg.com) -- Apelin is a recently discovered peptide that binds to the apelin (or APJ) G-protein-coupled receptor. Apelin-13 (NH2-QRPRLSHKGPMPF-COOH), one of several cleavage products of the proprotein ...
Jun 01, 2010 |
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