Coronary artery disease
hideCoronary artery disease (CAD)(or atherosclerotic heart disease) is the end result of the accumulation of atheromatous plaques within the walls of the coronary arteries that supply the myocardium (the muscle of the heart) with oxygen and nutrients. It is sometimes also called coronary heart disease (CHD), but although CAD is the most common cause of CHD, it is not the only cause.
CAD is the leading cause of death worldwide. While the symptoms and signs of coronary artery disease are noted in the advanced state of disease, most individuals with coronary artery disease show no evidence of disease for decades as the disease progresses before the first onset of symptoms, often a "sudden" heart attack, finally arises. After decades of progression, some of these atheromatous plaques may rupture and (along with the activation of the blood clotting system) start limiting blood flow to the heart muscle. The disease is the most common cause of sudden death, and is also the most common reason for death of men and women over 20 years of age. According to present trends in the United States, half of healthy 40-year-old males will develop CAD in the future, and one in three healthy 40-year-old women. According to the Guinness Book of Records, Northern Ireland is the country with the most occurrences of CAD. By contrast, the Maasai of Africa have almost no heart disease.
As the degree of coronary artery disease progresses, there may be near-complete obstruction of the lumen of the coronary artery, severely restricting the flow of oxygen-carrying blood to the myocardium. Individuals with this degree of coronary artery disease typically have suffered from one or more myocardial infarctions (heart attacks), and may have signs and symptoms of chronic coronary ischemia, including symptoms of angina at rest and flash pulmonary edema.
A distinction should be made between myocardial ischemia and myocardial infarction. Ischemia means that the amount of oxygen supplied to the tissue is inadequate to supply the needs of the tissue. When the myocardium becomes ischemic, it does not function optimally. When large areas of the myocardium becomes ischemic, there can be impairment in the relaxation and contraction of the myocardium. If the blood flow to the tissue is improved, myocardial ischemia can be reversed. Infarction means that the tissue has undergone irreversible death due to lack of sufficient oxygen-rich blood.
An individual may develop a rupture of an atheromatous plaque at any stage of the spectrum of coronary artery disease. The acute rupture of a plaque may lead to an acute myocardial infarction (heart attack).
For more information about Coronary artery disease, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with coronary artery disease
Hope for patients with type 2 diabetes
Dec 03, 2009 |
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The outlook for individuals with type 2 diabetes and coronary artery disease is not as grim as originally believed, according to new Saint Louis University research published in Circulation, the Journal of the American He ...
Preventing repeat strokes -- are survivors taking their medicine?
Dec 01, 2009 |
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Since 1999, stroke survivors have been advised to use aspirin, prescription antiplatelet agents, or prescription anticoagulants to help avoid another stroke. Many large surveys of the U.S. population have reported the use ...
Severe asymptomatic heart disease may accompany narrowing in leg arteries
Dec 01, 2009 |
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Results of a randomized, controlled clinical trial presented today at the annual meeting of the Radiological Society of North America (RSNA) reveal that one in five patients with narrowing or blockage in arteries that supply ...
Vitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
Nov 18, 2009 |
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The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing ...
New Test May Predict Heart Disease Events and the Effect of Weight Loss on Insulin Resistance
Nov 17, 2009 |
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(PhysOrg.com) -- Chemical fingerprints produced by the body's normal metabolic processes predict who will suffer cardiovascular events and who will benefit from weight loss by reduction of insulin resistance, according two ...
Women suffering sudden cardiac arrest have lower prevalence of structural heart disease than men
Nov 17, 2009 |
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A woman who suffers sudden cardiac arrest is significantly less likely than a man to exhibit the decrease in the heart's pumping ability that is widely recognized as a precursor, says a new study in the Nov. 24 Journal of ...
New study links vitamin D deficiency to cardiovascular disease and death
Nov 16, 2009 |
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While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong ...
Researchers using excimer laser angioplasty to blast arterial blockages in heart and kidneys
Nov 10, 2009 |
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(PhysOrg.com) -- Using an excimer laser to widen narrowed or obstructed blood vessels in hard-to-reach areas of heart and kidney arteries may be feasible and safe, according to a study by a team of researchers from the Virginia ...
Statins may worsen symptoms in some cardiac patients
Nov 03, 2009 |
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Although statins are widely used to prevent heart attacks, strokes, and other cardiovascular disorders, new research shows that the class of drugs may actually have negative effects on some cardiac patients. A new study presented ...
Quality improvement program increases hospitals' adherence to evidenced-based care
Oct 27, 2009 |
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Participation in the American Heart Association's Get With The Guidelines quality improvement program significantly improves hospitals' adherence to evidence-based therapies and reduces gender- and age-related disparities ...
Heart test found safe for pre-transplant kidney patients
Oct 15, 2009 |
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A screening test that measures whether a patient's heart is healthy enough for a kidney transplant is not as dangerous as once thought, according to a study appearing in an upcoming issue of the Clinical Journal of the Am ...
Calcium scans may be effective screening tool for heart disease
Sep 30, 2009 |
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A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death. Coronary artery calcium scans can be done without ...
Comprehensive cardiac CT scan may give clearer picture of significant heart disease
Sep 15, 2009 |
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A team of researchers led by Massachusetts General Hospital (MGH) radiologists has developed a computed-tomography-based protocol that identifies both narrowing of coronary arteries and areas of myocardial ischemia - restricted ...
Cutting sodium consumption: A major public health priority
Sep 14, 2009 |
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Reducing sodium intake is a major public health priority that must be acted upon by governments and nongovernmental organizations to improve population health, states an article in CMAJ (Canadian Medical Association Journal).
Diabetic patients require global care
Aug 31, 2009 |
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Diabetes mellitus-associated coronary artery disease (CAD) is assuming epidemic proportions, especially in western countries. Both coronary revascularization and medical management have improved tremendously over the last ...
