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Cytosol

The cytosol or intracellular fluid (or cytoplasmic matrix) is the liquid found inside cells, that is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into compartments.

The contents of a eukaryotic cell within the cell membrane (excluding the cell nucleus), is referred to as the cytoplasm. In prokaryotes, most of the chemical reactions of metabolism take place in the cytosol, while a few take place in membranes or in the periplasmic space. In eukaryotes, while many metabolic pathways still occur in the cytosol, others are contained within organelles.

The cytosol is a complex mixture of substances dissolved in water. Although water forms the large majority of the cytosol, its structure and properties within cells is not well understood. The concentrations of ions such as sodium and potassium are different in the cytosol than in the extracellular fluid; these differences in ion levels are important in processes such as osmoregulation and cell signaling. The cytosol also contains large amounts of macromolecules, which can alter how molecules behave, through macromolecular crowding.

Although once thought to be a simple solution of molecules, multiple levels of organization exist in the cytosol. These include concentration gradients of small molecules such as calcium, large complexes of enzymes that act together to carry out metabolic pathways, and protein complexes such as proteasomes and carboxysomes that enclose and separate parts of the cytosol.

For more information about Cytosol, read the full article at Wikipedia.
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How a molecular traffic jam impacts cell division

Interdisciplinary research between biology and physics aims to understand the cell and how it organizes internally. The mechanisms inside the cell are very complicated. LMU biophysicist Professor Erwin Frey, who is also a ...

Biology / Cell & Microbiology

created Nov 07, 2011 | popularity not rated yet | comments 0

Shuttle service in cells: Scientists find new components for protein transport

Research scientists at the Ruhr University Bochum discovered a new enzyme, which gives decisive insights into protein import into specific cellular organelles (peroxisomes). In the Journal of Biological Chemistry, the te ...

Chemistry / Biochemistry

created Jul 25, 2011 | popularity not rated yet | comments 0

A chaperone system guides tail-anchored membrane proteins to their destined membrane

Newly synthesized proteins can only fold into their correct three dimensional structure thanks to chaperones. In case of membrane proteins chaperones do not only prevent their aggregation, but also escort ...

Biology / Cell & Microbiology

created Jul 05, 2011 | popularity 5 / 5 (1) | comments 0

Stress protein Hsp12 provides a cellular survival mechanism never seen before

Despite clear evidence that Hsp12 -- a so-called heat shock or stress protein -- helps cells survive life-threatening conditions, how it works was an open question until now. The surprising answer is revealed ...

Biology / Cell & Microbiology

created Aug 26, 2010 | popularity 5 / 5 (1) | comments 0

How mitochondria get their membranes bent

Underneath their smooth surface mitochondria harbor an elaborately folded inner membrane. It holds a multitude of bottleneck like invaginations, which expand into elongated cavities. Now researchers have identified two proteins ...

Biology / Cell & Microbiology

created Jun 24, 2009 | popularity not rated yet | comments 0