Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei, and DNA tension plays a surprising role in this.
Cell & Microbiology
Apr 19, 2023
0
89
Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology ...
Cell & Microbiology
Mar 29, 2023
0
64
Recently, Professor Chunxiang You from Shandong Agricultural University and her colleagues published a review article titled "Regulation of fleshy fruit ripening: from transcription factors to epigenetic modifications" in ...
Molecular & Computational biology
Aug 8, 2022
0
22
The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired ...
Molecular & Computational biology
May 20, 2022
1
235
In human chromosomes, DNA is coated by proteins to form an exceedingly long beaded string. This "string" is folded into numerous loops, which are believed to help cells control gene expression and facilitate DNA repair, among ...
Cell & Microbiology
Apr 14, 2022
0
275
Diversity is good, especially when it comes to antibodies. It's long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies ...
Cell & Microbiology
Sep 13, 2019
0
59
DNA is a molecular manual that contains instructions for building life. And, like any manual, DNA isn't all that useful if it remains unopened and unread. In order to transcribe DNA, the enzyme RNA polymerase, or RNAP, must ...
Molecular & Computational biology
Jan 10, 2019
0
1
A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University and the Broad Institute of MIT and Harvard has created the first high-resolution 4-D map of genome folding, tracking an ...
Biotechnology
Oct 6, 2017
0
363
Have a close-up look at DNA; you'll see it wiggles in the oddest way. Put more scientifically, a piece of DNA's movements are often counterintuitive to those of objects in our everyday grasp. Take a rod of rubber, for example. ...
General Physics
Apr 20, 2016
0
183
Researchers have discovered the two-step process that activates an essential human enzyme, called Suv39h1, which is responsible for organizing large portions of the DNA found in every living cell.
Biochemistry
Feb 18, 2016
0
17
