How TFIIH uses XPG to located damaged DNA

Nucleotide excision repair (NER) is a critical DNA repair pathway that plays a key role in maintaining transcription and genome integrity by removing bulky DNA lesions.

Artificial intelligence folds RNA molecules

For the function of many biomolecules, their three-dimensional structure is crucial. Researchers are therefore not only interested in the sequence of the individual building blocks of biomolecules, but also in their spatial ...

Building blocks for RNA-based life abound at center of our galaxy

Nitriles, a class of organic molecules with a cyano group—that is, a carbon atom bound with a triple unsaturated bond to a nitrogen atom—are typically toxic. But paradoxically, they are also a key precursor for molecules ...

Crystal study may resolve DNA mystery

When cells reproduce, the internal mechanisms that copy DNA get it right nearly every time. Rice University bioscientists have uncovered a tiny detail that helps understand how the process could go wrong.

Novel method of labeling DNA bases for sequencing

An international research team headed by Michal Hocek of the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) and Charles University and Ciara K. O'Sullivan of Universitat Rovira ...

Understudied mutations have big impact on gene expression

An international team of researchers led by computer scientists at the University of California San Diego have identified 163 variable number tandem repeats (VNTRs) that actively regulate gene expression. In a paper published ...

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