Unconnected strands of DNA must be sealed together during genome replication and repair, and a new KAUST-led investigation shows how the fastening enzyme involved gets the job done.
Cell & Microbiology
Jan 24, 2023
0
65
The enzyme HDAC10 is involved in a variety of cellular processes associated with the development of a number of diseases. However, it is often not known exactly what role HDAC10 plays in the disease process. Scientists from ...
Biochemistry
Oct 12, 2022
0
28
The lab of Kathy Gould, Louise B. McGavock Professor and professor of cell and developmental biology, used a multi-disciplinary approach that included structural biology, biochemistry, and molecular biology to investigate ...
Cell & Microbiology
May 9, 2022
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21
Important advances in the understanding of DNA topoisomerases are discussed in a new review led by John Innes Centre researchers.
Cell & Microbiology
Mar 16, 2021
0
9
By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks—which drive every cellular process from protein ...
Cell & Microbiology
Oct 28, 2019
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23
The severe and debilitating genetic disease Xeroderma pigmentosum impedes cells to repair UV-induced DNA damage. Scientists from CeMM found a drug approved for diabetes treatment to alleviate the impact of the gene defect ...
Cell & Microbiology
Nov 20, 2017
0
3
One of the most potent toxins known acts by welding the two strands of the famous double helix together in a unique fashion which foils the standard repair mechanisms cells use to protect their DNA.
Biochemistry
Aug 2, 2017
0
138
Sunburn in living organisms is caused by ultraviolet (UV) light from the sun damaging the DNA in the cells. Many organisms, however, have an in-built mechanism for repairing the sun damage. This is possible thanks to an enzyme ...
Biochemistry
Jul 12, 2017
0
5
Microscopes that reveal the hidden complexities of life down to the nanoscale level have shown in exquisite detail how an enzyme involved in DNA repair works its molecular magic.
Cell & Microbiology
Apr 3, 2017
0
5
Scientists from the University of Sussex have discovered how an enzyme, known as PARP3, helps to accelerate the repair of DNA.
Cell & Microbiology
Sep 5, 2016
2
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