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Embryonic stem cell
hideEmbryonic stem cells (ES cells) are stem cells derived from the inner cell mass of an early stage embryo known as a blastocyst. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells.
Embryonic Stem (ES) cells are pluripotent. This means they are able to differentiate into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. These include each of the more than 220 cell types in the adult body. Pluripotency distinguishes ES cells from multipotent progenitor cells found in the adult; these only form a limited number of cell types. When given no stimuli for differentiation, (i.e. when grown in vitro), ES cells maintain pluripotency through multiple cell divisions. The presence of pluripotent adult stem cells remains a subject of scientific debate; however, research has demonstrated that pluripotent stem cells can be directly generated from adult fibroblast cultures.
Because of their plasticity and potentially unlimited capacity for self-renewal, ES cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. However Diseases treated by these non-embryonic stem cells include a number of blood and immune-system related genetic diseases, cancers, and disorders; juvenile diabetes; Parkinson's; blindness and spinal cord injuries. Besides the ethical concerns of stem cell therapy (see stem cell controversy), there is a technical problem of graft-versus-host disease associated with allogeneic stem cell transplantation. However, these problems associated with histocompatibility may be solved using autologous donor adult stem cells or via therapeutic cloning.
For more information about Embryonic stem cell, read the full article at
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News tagged with embryonic stem cells
When is a stem cell really a stem cell?
Nov 24, 2009 |
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(PhysOrg.com) -- Induced pluripotent stem (iPS) cells -- adult cells reprogrammed to look and function like versatile embryonic stem cells -- are of growing interest in medicine. They may provide a way to ...
Stem cells restore mobility in neck-injured rats (w/ Video)
Nov 10, 2009 |
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(PhysOrg.com) -- The first human embryonic stem cell treatment approved by the FDA for human testing has been shown to restore limb function in rats with neck spinal cord injuries - a finding that could expand the clinical ...
Study suggests adult stem cells may help repair hearts damaged by heart attack
7 hours ago |
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Adult stem cells may help repair heart tissue damaged by heart attack according to the findings of a new study to be published in the December 8 issue of the Journal of the American College of Cardiology. Results from t ...
New stem cell lines approved for tax-paid research
12 hours ago |
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(AP) -- Scientists can start using taxpayer dollars to do research with 13 batches of embryonic stem cells and the government says dozens more cell lines should be available soon, opening a new era for the potentially life-saving ...
Stem cells alleviate tumor treatment side effects
Nov 17, 2009 |
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(PhysOrg.com) -- Human embryonic stem cells could help people with learning and memory deficits after radiation treatment for brain tumors, suggests a new UC Irvine study.
Lung tissue generated from human embryonic stem cells
Nov 05, 2009 |
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Scientists in Belgium have successfully differentiated human embryonic stem cells (hESC) into major cell types of lung epithelial tissue using a convenient air-liquid interface. The technique, published in BioMed Central's ...
Embryonic stem cell therapy closer to human trials
Nov 19, 2009 |
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Embryonic stem cell therapy got a step closer to the clinic Thursday after US researchers said they filed a request for government approval of human trials.
On your last nerve: Researchers advance understanding of stem cells
Nov 17, 2009 |
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Researchers from North Carolina State University have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance ...
Stem cells restore cognitive abilities impaired by brain tumor treatment, study finds
Nov 09, 2009 |
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Human embryonic stem cells could help people with learning and memory deficits after radiation treatment for brain tumors, suggests a new UC Irvine study.
Japan scientists attack govt research cut plans
Nov 26, 2009 |
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Top Japanese scientists, including four Nobel laureates, have criticised the new government for plans to slash research budgets, warning the country will loose its high-tech edge.
First reconstitution of an epidermis from human embryonic stem cells
Nov 20, 2009 |
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Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM Institute (France), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has su ...
Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Nov 18, 2009 |
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Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. ...
