Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer's, Parkinson's, and Huntington's diseases. Cells work constantly to eliminate misfolded ...
Cell & Microbiology
Apr 20, 2023
0
121
Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag's N-terminal ...
Molecular & Computational biology
Jun 21, 2022
0
82
Cell division ensures growth or renewal and is thus vital for all organisms. However, the process differs somewhat in animals, bacteria, fungi, plants, and algae. Until now, little was known about how cell division occurs ...
Cell & Microbiology
Feb 15, 2022
0
303
Within a cell, the nucleus is surrounded by the nuclear envelope—two layers of phospholipid membrane that prevents the nucleus mixing with other parts of the cell, thus protecting the cell's DNA from outside damage.
Cell & Microbiology
Dec 8, 2021
0
373
A study has solved a long-standing debate about the transport of essential proteins, implicated in many human diseases, through one of the cell's most complex and sophisticated structures.
Molecular & Computational biology
May 4, 2020
0
255
In eukaryotic cells, the nucleus is walled off from the rest of the cell by the nuclear envelope. All transport into and out of the nucleus occurs via cylindrical channels called nuclear pore complexes (NPCs) that penetrate ...
Cell & Microbiology
Jun 12, 2019
0
3
Multiple components of the nuclear pore complex and nuclear import machinery enable a protein called human myxovirus resistance 2 (MX2) to inhibit HIV-1 infection, according to a study published November 29 in the open-access ...
Cell & Microbiology
Nov 29, 2018
0
16
The deadly Nipah virus and others like it assemble themselves in a much more haphazard manner than previously thought, new UBC research has found. The discovery could allow scientists to develop more effective vaccines and ...
Analytical Chemistry
Aug 16, 2018
0
7
For the first time, scientists have directly visualized in real-time structural changes in the surface protein of the influenza virus that may help the virus to fuse with and enter target cells before hijacking their functions. ...
Cell & Microbiology
Jun 28, 2018
0
17
Scientists at A*STAR have revealed how microtubules, part of a cell's 'skeleton," position the multiple nuclei in muscle cells. Malfunctions in this crucial developmental process are linked to muscular dystrophies, a group ...
Cell & Microbiology
Mar 16, 2018
0
4
