News tagged with er stress
Level of cellular stress determines longevity of retinal cells
Apr 28, 2009 |
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(PhysOrg.com) -- Stress can be adaptive. It can make you sharper, help you focus and it can even improve your performance. But too much of it can tax cells to the point where they can no longer cope and slowly ...
Obesity: Reviving the promise of leptin
Biology /
Jan 06, 2009 |
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(PhysOrg.com) -- The discovery more than a decade ago of leptin, an appetite-suppressing hormone secreted by fat tissue, generated headlines and great hopes for an effective treatment for obesity. But hopes ...
Protective pathway in stressed cells not so helpful when it comes to prions
Sep 15, 2008 |
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Scientists at the National Institutes of Health (NIH) have discovered that an important cellular quality control mechanism may actually be toxic to some brain cells during prion infection. The research, published by Cell ...
Potential to prevent loss of insulin in type 2 diabetes
Jul 14, 2008 |
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There are two completely different diseases known as diabetes. Type 1 is an autoimmune condition that often starts in childhood or adolescence. Type 2 is a metabolic disorder sometimes associated with lifestyle. In both cases, ...
Search results for er stress
Prolonged stress sparks ER to release calcium stores and induce cell death in aging-related diseases
Sep 14, 2009 |
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Li et al. explain how prolonged stress sparks the endoplasmic reticulum (ER) to release its calcium stores, inducing cells to undergo apoptosis in several aging-related diseases.The study will appear in the September 21, ...
Not all fat is created equal
Aug 27, 2008 |
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A Temple University study finds fat in obese patients is "sick" when compared to fat in lean patients.
Cellular stress causes fatty liver disease in mice
Biology /
Dec 08, 2008 |
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A University of Iowa researcher and colleagues at the University of Michigan have discovered a direct link between disruption of a critical cellular housekeeping process and fatty liver disease, a condition that causes fat ...
The battle for CRTC2: How obesity increases the risk for diabetes
Jun 21, 2009 |
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Obesity is probably the most important factor in the development of insulin resistance, but science's understanding of the chain of events is still spotty. Now, researchers at the Salk Institute for Biological ...
Mutant gene's true effect revealed - giving new therapy hope
Oct 19, 2009 |
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(PhysOrg.com) -- Scientists have revealed how a mutant gene that causes a connective tissue disease resulting in dwarfism does so by significantly affecting the inside of cells - opening up new therapy strategies that involve ...
Discovery of gene mechanism could bring about new ways to treat metastatic cancer
Jul 01, 2008 |
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Virginia Commonwealth University and VCU Massey Cancer Center researchers have uncovered how a gene, melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), induces a bystander effect that kills cancer cells ...
Researchers shed light on mechanism of action used by anti-cancer drug
Jun 11, 2007 |
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Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new mechanism of action of the anti-cancer drug sorafenib, which could stimulate the development of novel regimens in which it is combined ...
RING finger protein 5 may guide treatment for muscle disease in older adults
Apr 04, 2008 |
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Researchers at the Burnham Institute for Medical Research (Burnham) have discovered a new player in the development of a disorder called Sporadic Inclusion Body Myositis (sIBM). sIBM is a muscle disease that affects predominantly ...
Calcium aids protein folding as therapy for enzymes in types of lysosomal storage diseases
Biology /
Feb 05, 2008 |
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Lysosomes are organelles that break down macromolecules in a cell, and this process is crucial for maintaining healthy cells. A lysosomal storage disease results from deficient activity of the hydrolytic enzymes, responsible ...
Using Simple Genome, Researchers Move Personalized Medicine Closer to Reality
Oct 14, 2009 |
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(PhysOrg.com) -- Researchers at Columbia University have developed a statistical method that accurately predicts how an organism will respond to dozens of commonly used drugs. This clinical and conceptual advance moves medical ...
List of search results for er stress
