Researcher proposes paradigm shift in enzyme biochemistry

Although you may never have heard of the cytochrome P450 superfamily of enzymes, these proteins play diverse and critical roles in humans through the metabolic processing of drugs, pesticides, fatty acids, fat-soluble vitamins, ...

A novel pathway regulating lipid biosynthesis by fatty acids

Researchers have been studying the transcription factor, SREBP, a critical regulator of lipid biosynthesis. Precursor SREBP proteins, located in the endoplasmic reticulum (ER) of the cell, are transported through the Golgi ...

Bioenergetics of rapid pollen tube growth

Sexual reproduction of plants requires pollen to land on the stigma, which then germinates and grows pollen tubes through the style to deliver sperm cells to the ovule. Pollen tubes are the fastest-growing plant cells known. ...

Modern humans generate more brain neurons than Neandertals

The question of what makes modern humans unique has long been a driving force for researchers. Comparisons with our closest relatives, the Neandertals, therefore provide fascinating insights. The increase in brain size, and ...

New approach could overcome fungal resistance to current treatments

Current medications aren't particularly effective against fungi. The situation is becoming more challenging because these organisms are developing resistance to antimicrobial treatments, just as bacteria are. Now, researchers ...

Cold-sensitive staphylococci reveal a weakness

Staphylococcus aureus—also known as "golden staph"—has the ability to develop in highly variable environmental conditions (on the skin, in the nose, on sterile surfaces, and so forth). Its great adaptability depends on ...

Dozens of potential new antibiotics discovered with free online app

A new web tool speeds the discovery of drugs to kill Gram-negative bacteria, which are responsible for the overwhelming majority of antibiotic-resistant infections and deaths. The tool also offers insights into discrete chemical ...

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