Related topics: cells · mitochondria · antioxidants

Shining light on the radical production of DNA building blocks

Despite its fundamental role in biology and extensive studies over half a century, many aspects of how DNA's building blocks are formed remain unclear. Now, an international team of scientists has revealed valuable details ...

A 'toolbox of biocatalysts' improves control over free radicals

One of the central challenges for synthetic chemists is to impose control over free radicals. Highly reactive molecules with an unpaired electron, free radicals, may be familiar to you; these are the type of molecules we ...

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Radical (chemistry)

In chemistry, radicals (often referred to as free radicals) are atoms, molecules, or ions with unpaired electrons on an otherwise open shell configuration. These unpaired electrons are usually highly reactive, so radicals are likely to take part in chemical reactions. Radicals play an important role in combustion, atmospheric chemistry, polymerization, plasma chemistry, biochemistry, and many other chemical processes, including human physiology. For example, superoxide and nitric oxide regulate many biological processes, such as controlling vascular tone. "Radical" and "free radical" are frequently used interchangeably, although a radical may be trapped within a solvent cage or be otherwise bound. The first organic free radical identified was triphenylmethyl radical, by Moses Gomberg in 1900 at the University of Michigan.

Historically, the term radical has also been used for bound parts of the molecule, especially when they remain unchanged in reactions. These are now called functional groups. For example, methyl alcohol was described as consisting of a methyl "radical" and a hydroxyl "radical". Neither are radicals in the modern chemical sense, as they are permanently bound to each other, and have no unpaired, reactive electrons. They can, however, be observed as radicals in mass spectrometry after breaking down the substance with a hail of energetic electrons.

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