News tagged with gene amplification
Signaling pathway linked to inflammatory breast cancer may drive disease metastasis
Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.
Nov 13, 2011 |
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Enzyme necessary for DNA synthesis can also erase DNA
In this week's edition of Proceedings of the National Academy of Sciences, PNAS, Uppsala University scientists describe a new mechanism behind an important process that causes a rapid reduction of DNA in the chromosomes of bac ...
Jun 08, 2009 |
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Discovery predicts patient sensitivity to important drug target in deadly brain cancer
A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma – the most common and most aggressive malignant brain tumor ...
Feb 06, 2012 |
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Studies help clarify the role of lapatinib and trastuzumab in treating HER2 positive breast cancer
In patients with HER2-positive breast cancer, Tykerb (lapatinib) has been used both in combination with herceptin (trastuzumab) and as an alternative single-agent therapy for pre-surgery (neo-adjuvant) chemotherapy treatment. ...
Jan 16, 2012 |
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Simpler times: Did an earlier genetic molecule predate DNA and RNA?
(PhysOrg.com) -- In the chemistry of the living world, a pair of nucleic acids—DNA and RNA—reign supreme. As carrier molecules of the genetic code, they provide all organisms with a mechanism for ...
Jan 09, 2012 |
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SWI/SNF protein complex plays role in suppressing pancreatic tumors: study
A well-known protein complex responsible for controlling how DNA is expressed plays a previously unsuspected role in preventing pancreatic cancer, according to researchers at the Stanford University School of Medicine.
Jan 09, 2012 |
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First genome sequencing clinical trial for triple negative cancer points to new treatments
Initial results from an ongoing clinical trial, the first designed to examine the utility of whole-genome sequencing for triple negative breast cancer, were reported today during the CRTC-AACR San Antonio Breast Cancer Symposium.
Dec 08, 2011 |
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Study finds amplification of multiple cell-growth genes in some brain tumors
A small percentage of the deadly brain tumors called glioblastomas, which usually resist treatment with drugs targeting mutations in cell-growth genes, appears to contain extra copies of two or three of these genes at the ...
Dec 01, 2011 |
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Stem cell study advances regenerative medicine research
Researchers from A*STAR Singapore took lead roles in a study that identified a portion of the genome mutated during long-term culture of human embryonic stem cells (hESCs). The study was a worldwide collaboration, led by ...
Nov 28, 2011 |
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International initiative to address safety issues in stem cell therapy
An international study, published today in the prestigious journal Nature Biotechnology, reveals more about human pluripotent stem cells and their genetic stability and has important implications for the development of the ...
Nov 28, 2011 |
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Antifolates show promise against NSCLC subtype
Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study conducted by Quintiles comparing human lung cancer ...
Nov 14, 2011 |
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Study evaluates risk factors for chronic TMJD
Thousands of Americans this year will be diagnosed with a common disorder of the jaw area called temporomandibular joint and muscle disorders (TMJD, formerly called TMJ). Because of the inherent biological complexity of TMJD, ...
Nov 10, 2011 |
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