News tagged with gene amplification
Enzyme necessary for DNA synthesis can also erase DNA
Jun 08, 2009 |
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In this week's edition of Proceedings of the National Academy of Sciences, PNAS, Uppsala University scientists describe a new mechanism behind an important process that causes a rapid reduction of DNA in the chromosomes of bac ...
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Which is promising as therapeutic targets in patients with biliary tract cancer? EGFR or HER2?
Oct 16, 2009 |
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A research team from Germany analyzed the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2) in patients with advanced ...
Scientists Uncover Rules for Gene Amplification
Jun 29, 2006 |
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Gene amplification plays an important role in causing cancers via activation of oncogenes. If scientists can determine the rules as to which segments of genetic material become amplified and how, oncologists and drug researchers ...
HER2 levels may aid in treatment selection for metastatic breast cancer
Dec 02, 2008 |
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Findings published in the December 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show lapatinib benefits women with HER2-positive breast cancer, while women with H ...
St. Jude finds 'dancing' hair cells are key to humans' acute hearing
May 07, 2008 |
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St. Jude Children's Research Hospital investigators have found that an electrically powered amplification mechanism in the cochlea of the ear is critical to the acute hearing of humans and other mammals. The findings will ...
Analysis of Breast-Cancer Gene Role Offers Promising Target for Drugs to Stop Or Slow Progression
Oct 31, 2006 |
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Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.
Mass copying of genes speeds up evolution
Biology /
Oct 31, 2006 |
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In the latest issue of PNAS, Proceedings of the National Academy of Sciences, a Swedish-American team of researchers show how selective gene amplification-mass copying of a specific gene-can increase the speed with which ...
Gene alterations associated with response to anthracycline therapy for breast cancer
Apr 28, 2009 |
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Alterations in the topoisomerase II alpha (TOP2A) gene were associated with better patient outcomes following anthracycline-based therapy compared with non-anthracycline-based regimens, according to a study in the April ...
Gene screen to identify causes of autism
Oct 16, 2008 |
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A new screening method can be used to detect the chromosomal abnormalities most commonly associated with autism spectrum disorders. By screening for genetic defects associated with various kinds of cognitive impairment, the ...
Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
Aug 16, 2009 |
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A study published in this week's online issue of Nature Biotechnology, demonstrates a unique and highly sensitive method for detecting methylation-associated cancers.
Novel marker of colon cancer
Oct 23, 2008 |
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Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide. Until now, several molecules have been reported to play an important role in gastroenterological ...
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