News tagged with gene fusion
Jak of all trades? Not of leukaemia therapy
About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition ...
Jan 30, 2012 |
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Genetic composition of multicentric lung tumors appears to be similar
Multicentric carcinogenesis with the same genetic mutation appears to occur in lung adenocarcinoma, according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and ...
Jan 09, 2012 |
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Gene fusion in lung cancer afflicting never-smokers may be target for therapy
Smoking is a well-known risk factor for lung cancer, but nearly 25% of all lung cancer patients have never smoked. In a study published online today in Genome Research, researchers have identified a previously unknown gene f ...
Dec 22, 2011 |
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Discovery of gene fusion in ovarian cancer could lead to earlier diagnoses
About 15 percent of cases of an aggressive, difficult-to-detect form of ovarian cancer contain a unique fusion between two neighboring, normally separate genes, say researchers at the Stanford University School of Medicine. ...
Sep 20, 2011 |
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First and only therapeutic drug for ALK-positive lung cancer approved
In a major triumph for personalized medicine, the FDA approved the drug crizotinib for use with the lung cancer type known as ALK-positive.
Aug 31, 2011 |
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Half of prostate cancers could potentially benefit from new type of cancer drugs, study finds
About half of prostate cancers have a genetic anomaly that appears to make tumor cells responsive to a new class of cancer-fighting drugs, a new study from the University of Michigan Comprehensive Cancer Center finds.
May 18, 2011 |
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New fusion gene plays role in some stomach cancers
A newly discovered hybrid gene appears to play a direct role in some stomach cancers, according to an international team of scientists led by researchers at Duke-NUS Graduate Medical School Singapore.
Apr 06, 2011 |
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Cell death pathway linked to mitochondrial fusion
New research led by UC Davis scientists provides insight into why some body organs are more susceptible to cell death than others and could eventually lead to advances in treating or preventing heart attack or stroke.
Jan 24, 2011 |
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New discovery offers hope for the prevention of prostate cancer
(PhysOrg.com) -- Scientists may have found the key to preventing prostate cancer, according to promising new research, published in the journal Cancer Research.
Nov 16, 2010 |
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Prostate cancer's multiple personalities revealed
Scientists at Weill Cornell Medical College have taken an important step toward a better understanding of prostate cancer by uncovering evidence that it is not one disease, as previously believed, but rather several factors ...
Nov 03, 2010 |
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New lung cancer drug shows dramatic results for shrinking tumors
Patients with a specific kind of lung cancer may benefit from a Phase III clinical trial offered by the Moores UCSD Cancer Center. The new drug, crizotinib, under development by Pfizer, showed dramatic results in reducing ...
Jun 22, 2010 |
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Gene fusions may be the 'smoking gun' in prostate cancer development
Prostate cancer treatments that target the hormone androgen and its receptor may be going after the wrong source, according to a new study. Researchers have found that when two genes fuse together to cause ...
May 18, 2010 |
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Melanoma transcriptome reveals novel genomic alterations not seen before
Melanoma, the most deadly form of skin cancer, afflicts more than 50,000 people in the United States annually and the incidence rate continues to rise. In a study published online in Genome Research, scientists have delved ...
Feb 22, 2010 |
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Study points way to development of drugs for deadly childhood leukemia
A new study could point the way to the development of better drugs to fight a deadly form of childhood leukemia called mixed-lineage leukemia (MLL).
Dec 14, 2009 |
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Study uncovers key to how 'triggering event' in cancer occurs
Researchers at the University of Michigan Comprehensive Cancer Center have discovered what leads to two genes fusing together, a phenomenon that has been shown to cause prostate cancer to develop.
Oct 29, 2009 |
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