Mutation

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In biology, mutations are changes to the nucleotide sequence of the genetic material of an organism. Mutations can be caused by copying errors in the genetic material during cell division, by exposure to ultraviolet or ionizing radiation, chemical mutagens, or viruses, or can be induced by the organism itself, by cellular processes such as hypermutation. In multicellular organisms with dedicated reproductive cells, mutations can be subdivided into germ line mutations, which can be passed on to descendants through the reproductive cells, and somatic mutations, which involve cells outside the dedicated reproductive group and which are not usually transmitted to descendants. If the organism can reproduce asexually through mechanisms such as cuttings or budding the distinction can become blurred. For example, plants can sometimes transmit somatic mutations to their descendants asexually or sexually where flower buds develop in somatically mutated parts of plants. A new mutation that was not inherited from either parent is called a de novo mutation. The source of the mutation is unrelated to the consequence, although the consequences are related to which cells were mutated.

Mutations create variation within the gene pool. Less favorable (or deleterious) mutations can be reduced in frequency in the gene pool by natural selection, while more favorable (beneficial or advantageous) mutations may accumulate and result in adaptive evolutionary changes. For example, a butterfly may produce offspring with new mutations. The majority of these mutations will have no effect; but one might change the color of one of the butterfly's offspring, making it harder (or easier) for predators to see. If this color change is advantageous, the chance of this butterfly surviving and producing its own offspring are a little better, and over time the number of butterflies with this mutation may form a larger percentage of the population.

Neutral mutations are defined as mutations whose effects do not influence the fitness of an individual. These can accumulate over time due to genetic drift. It is believed that the overwhelming majority of mutations have no significant effect on an organism's fitness. Also, DNA repair mechanisms are able to mend most changes before they become permanent mutations, and many organisms have mechanisms for eliminating otherwise permanently mutated somatic cells.

Mutation is generally accepted by the scientific community as the mechanism upon which natural selection acts, providing the advantageous new traits that survive and multiply in offspring or disadvantageous traits that die out with weaker organisms.

For more information about Mutation, read the full article at Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.


News tagged with gene mutation

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Schizophrenia gene's role may be broader, more potent, than thought

Medicine & Health / Research

created Nov 19, 2009 | popularity 5 / 5 (1) | comments 0

(PhysOrg.com) -- UCSF scientists studying nerve cells in fruit flies have uncovered a new function for a gene whose human equivalent may play a critical role in schizophrenia.


New advice: Skip mammograms in 40s, start at 50 (AP)

New mammogram advice raises questions, concerns

Medicine & Health / Cancer

created Nov 16, 2009 | popularity not rated yet | comments 0

(AP) -- For many women, getting a mammogram is already one of life's more stressful experiences. Now, women in their 40s have the added anxiety of trying to figure out if they should even be getting one at ...


Fish go mad for ginger gene

Fish go mad for ginger gene

Biology / Plants & Animals

created Sep 28, 2009 | popularity 5 / 5 (1) | comments 0

There may be plenty of fish in the sea but the medaka knows what it likes. A new study published in the open access journal BMC Biology shows how a single gene mutation that turns Japanese Killifish a drab ...


Researchers create first targeted knockout rats using zinc finger nuclease technology

Biology / Biotechnology

created Jul 23, 2009 | popularity 5 / 5 (5) | comments 6

Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., Sigma-Aldrich Corporation, Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically ...


Fish oil protects against diseases like Parkinson's, study

Medicine & Health / Health

created Apr 19, 2009 | popularity 4.7 / 5 (7) | comments 0

Dr. Nicolas Bazan, Director of the Neuroscience Center of Excellence, Boyd Professor, and Ernest C. and Yvette C. Villere Chair of Retinal Degenerative Diseases Research at LSU Health Sciences Center New Orleans, will present ...


Higher incidence of thyroid cancer in volcanic area of Sicily

Medicine & Health / Cancer

created Nov 05, 2009 | popularity not rated yet | comments 0

People living in volcanic areas may be at a higher risk for thyroid cancer, according to a new study published online November 5 in the Journal of the National Cancer Institute.


Nine new X chromosome genes associated with learning disabilities

Nine new X chromosome genes associated with learning disabilities

Medicine & Health / Genetics

created Apr 19, 2009 | popularity 5 / 5 (3) | comments 0

(PhysOrg.com) -- A collaboration between more than 70 researchers across the globe has uncovered nine new genes on the X chromosome that, when knocked-out, lead to learning disabilities. The international ...


Survival of the healthiest: Selective eradication of malignant cells

Medicine & Health / Cancer

created Nov 05, 2009 | popularity 5 / 5 (1) | comments 0

The ultimate goal in cancer research, a treatment that kills cancer cells whilst leaving healthy cells untouched, is brought nearer by the success of a new therapeutic approach. The potential therapy, published in BioMed ...


Scientists find autism-associated synapse alterations

Medicine & Health / Research

created Oct 12, 2009 | popularity 4.8 / 5 (4) | comments 0

A Stanford University School of Medicine researcher has pinpointed the mechanism by which a gene associated with both autism and schizophrenia influences behavior in mice.


Discovery leads to rapid mouse 'personalized trials' in breast cancer

Medicine & Health / Cancer

created Sep 04, 2009 | popularity not rated yet | comments 1

One person's breast cancer is not the same as another person's, because the gene mutations differ in each tumor. That makes it difficult to match the best therapy with the individual patient.


Team reveals molecular mechanism underlying a form of diabetes

Medicine & Health / Research

created Sep 08, 2009 | popularity 5 / 5 (1) | comments 0

By investigating a rare and severe form of diabetes in children, University of Iowa researchers have discovered a new molecular mechanism that regulates specialized pancreatic cells and insulin secretion. The mechanism involves ...


Biologists identify the molecular basis of high-altitude adaptation in mice

Biologists identify the molecular basis of high-altitude adaptation in mice

Biology / Evolution

created Aug 10, 2009 | popularity not rated yet | comments 0

(PhysOrg.com) -- Biologists have long known how adaptive evolution works. New mutations arise within a population and those that confer some benefits to the organism increase in frequency and eventually become ...


Study: 7 key genes predict brain cancer survival

Medicine & Health / Cancer

created Jul 14, 2009 | popularity not rated yet | comments 1

(AP) -- Scientists have found seven key genes in the type of brain tumor affecting Sen. Edward Kennedy that together can predict how aggressive a patient's cancer will be.


Protein-protein interaction explains vision loss in genetic diseases

Medicine & Health / Genetics

created May 10, 2009 | popularity not rated yet | comments 1

The mystery of genetic disease is only partially solved with the identification of a mutated gene. Often, the pattern of disease - the features or disorders associated with it - vary in type and severity among those who are ...


Muscular dystrophy mystery solved; scientists move closer to MD solution

Medicine & Health / Diseases

created Feb 26, 2009 | popularity 4.9 / 5 (7) | comments 0

Muscular dystrophy, which affects approximately 250,000 people in the United States, occurs when damaged muscle tissue is replaced with fibrous, bony or fatty tissue and loses function. While scientists have identified one ...