Mutation

hide

In biology, mutations are changes to the nucleotide sequence of the genetic material of an organism. Mutations can be caused by copying errors in the genetic material during cell division, by exposure to ultraviolet or ionizing radiation, chemical mutagens, or viruses, or can be induced by the organism itself, by cellular processes such as hypermutation. In multicellular organisms with dedicated reproductive cells, mutations can be subdivided into germ line mutations, which can be passed on to descendants through the reproductive cells, and somatic mutations, which involve cells outside the dedicated reproductive group and which are not usually transmitted to descendants. If the organism can reproduce asexually through mechanisms such as cuttings or budding the distinction can become blurred. For example, plants can sometimes transmit somatic mutations to their descendants asexually or sexually where flower buds develop in somatically mutated parts of plants. A new mutation that was not inherited from either parent is called a de novo mutation. The source of the mutation is unrelated to the consequence, although the consequences are related to which cells were mutated.

Mutations create variation within the gene pool. Less favorable (or deleterious) mutations can be reduced in frequency in the gene pool by natural selection, while more favorable (beneficial or advantageous) mutations may accumulate and result in adaptive evolutionary changes. For example, a butterfly may produce offspring with new mutations. The majority of these mutations will have no effect; but one might change the color of one of the butterfly's offspring, making it harder (or easier) for predators to see. If this color change is advantageous, the chance of this butterfly surviving and producing its own offspring are a little better, and over time the number of butterflies with this mutation may form a larger percentage of the population.

Neutral mutations are defined as mutations whose effects do not influence the fitness of an individual. These can accumulate over time due to genetic drift. It is believed that the overwhelming majority of mutations have no significant effect on an organism's fitness. Also, DNA repair mechanisms are able to mend most changes before they become permanent mutations, and many organisms have mechanisms for eliminating otherwise permanently mutated somatic cells.

Mutation is generally accepted by the scientific community as the mechanism upon which natural selection acts, providing the advantageous new traits that survive and multiply in offspring or disadvantageous traits that die out with weaker organisms.

For more information about Mutation, read the full article at Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.


News tagged with gene mutation

results timeline


New 'molecular clock' aids dating of human migration history

Biology / Cell & Microbiology

created Jun 04, 2009 | popularity 4.3 / 5 (9) | comments 0

Researchers at the University of Leeds have devised a more accurate method of dating ancient human migration - even when no corroborating archaeological evidence exists.


Muscular dystrophy mystery solved; scientists move closer to MD solution

Medicine & Health / Diseases

created Feb 26, 2009 | popularity 4.9 / 5 (7) | comments 0

Muscular dystrophy, which affects approximately 250,000 people in the United States, occurs when damaged muscle tissue is replaced with fibrous, bony or fatty tissue and loses function. While scientists have identified one ...


Fish oil protects against diseases like Parkinson's, study

Medicine & Health / Health

created Apr 19, 2009 | popularity 4.7 / 5 (7) | comments 0

Dr. Nicolas Bazan, Director of the Neuroscience Center of Excellence, Boyd Professor, and Ernest C. and Yvette C. Villere Chair of Retinal Degenerative Diseases Research at LSU Health Sciences Center New Orleans, will present ...


Researchers create first targeted knockout rats using zinc finger nuclease technology

Biology / Biotechnology

created Jul 23, 2009 | popularity 5 / 5 (5) | comments 6

Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., Sigma-Aldrich Corporation, Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically ...


Scientists find autism-associated synapse alterations

Medicine & Health / Research

created Oct 12, 2009 | popularity 4.8 / 5 (4) | comments 0

A Stanford University School of Medicine researcher has pinpointed the mechanism by which a gene associated with both autism and schizophrenia influences behavior in mice.


Researchers discover gene mutation that helps prevent heart disease

Medicine & Health / Genetics

created Dec 11, 2008 | popularity 5 / 5 (3) | comments 0

Researchers at the University of Maryland School of Medicine in Baltimore have discovered a novel gene mutation among the Old Order Amish population that significantly reduces the level of triglycerides in the blood and appears ...


Nine new X chromosome genes associated with learning disabilities

Nine new X chromosome genes associated with learning disabilities

Medicine & Health / Genetics

created Apr 19, 2009 | popularity 5 / 5 (3) | comments 0

(PhysOrg.com) -- A collaboration between more than 70 researchers across the globe has uncovered nine new genes on the X chromosome that, when knocked-out, lead to learning disabilities. The international ...


Tiny differences in our genes help shed light on the big picture of human history

Medicine & Health / Genetics

created Apr 30, 2009 | popularity 5 / 5 (3) | comments 1

(PhysOrg.com) -- By examining very small differences in people's genes, scientists from Cornell University have developed a new tool for identifying big events in human history and pinpointing the origins of specific gene ...


Dalmatian bladder stones caused by gene that regulates uric acid in humans

Biology /

created Nov 07, 2008 | popularity 5 / 5 (2) | comments 1

A gene mutation that causes high levels of uric acid in all Dalmatian dogs and bladder stones in some Dalmatians, has been identified by a team of researchers in the School of Veterinary Medicine at the University of California, ...


Scientists clarify editing error underlying genetic neurodegenerative disease

Biology /

created Jan 28, 2009 | popularity 5 / 5 (2) | comments 0

Two molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia ...


New glaucoma research solves anthropological and medical puzzle

Medicine & Health / Genetics

created Apr 15, 2009 | popularity 5 / 5 (2) | comments 0

Scientists studying a rare form of glaucoma have discovered why people in the disparate Roma communities are at greater risk of inheriting a condition leading to permanent blindness than other groups in the population.


Discovery of a debilitating genetic syndrome

Medicine & Health / Genetics

created Dec 05, 2008 | popularity 4.5 / 5 (2) | comments 0

Canadian researchers announce the discovery of MEDNIK Syndrome, a debilitating genetic syndrome. In a study published today in the online version of PLoS Genetics, and in the December edition, a research team led by Dr. Patrick ...


Mutated gene in zebrafish sheds light on blindness in humans

Mutated gene in zebrafish sheds light on blindness in humans

Medicine & Health / Research

created Mar 24, 2009 | popularity 5 / 5 (1) | comments 0

Among zebrafish, the eyes have it. Inside them is a mosaic of light-sensitive cells whose structure and functions are nearly identical to those of humans. There, biologists at The Florida State University ...


Scientists identify chemical compound that may stop deadly brain tumors

Medicine & Health / Cancer

created Apr 09, 2009 | popularity 5 / 5 (1) | comments 0

Researchers at the University of North Carolina at Chapel Hill School of Medicine have identified a compound that could be modified to treat one of the most deadly types of cancer, and discovered how a particular gene mutation ...


Two-pronged model could help foil tough cystic fibrosis infections

Biology / Cell & Microbiology

created Apr 24, 2009 | popularity 5 / 5 (1) | comments 0

Dartmouth Medical School researchers have devised a novel approach for thwarting the relentless bacterial infections that thrive in the lungs of people with cystic fibrosis (CF), unlocking new possibilities against a tenacious ...