News tagged with gene splicing
Massive DNA search uncovers new mutations driving blood cancer
The most comprehensive search to date of DNA abnormalities in chronic lymphocytic leukemia (CLL) has unearthed several new altered genes that drive this common blood cancer, a finding that could potentially ...
Dec 12, 2011 |
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Genetic screening in yeast reveals new candidate gene for Lou Gehrig's disease
(Medical Xpress) -- Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a universally fatal neurodegenerative disease. Mutations in two related proteins, TDP-43 and FUS, cause some forms of ALS. ...
Nov 15, 2011 |
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Many hereditary conditions associated with errors in pre-mRNA splicing, study suggests
A new Brown University computer analysis that predicts the effect of genetic mutations on how the body splices mRNA indicates as many as a third of disease-related mutations may be linked to splicing problems -- more than ...
Jun 13, 2011 |
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Cancer-associated long non-coding RNA regulates pre-mRNA splicing
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the ...
Sep 23, 2010 |
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Of yeast and men: Unraveling the molecular mechanisms of Friedreich's ataxia
Researchers in human genetics have long known that expansions of GAA repeats - resulting in this nucleotide triplet repeating hundreds or thousands of times - cause the most common hereditary neurological disorder known as ...
Jul 09, 2009 |
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Getting more from whole-transcript microarrays
The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published today in the ...
May 21, 2009 |
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Siestas Among the Drosophilae
(PhysOrg.com) -- Isaac Edery is concerned with biological clocks, internal mechanisms that enable virtually all plants and animals to behave in rhythmic biological cycles known as circadian rhythms.
Biology /
Jan 28, 2009 |
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Scientists clarify editing error underlying genetic neurodegenerative disease
Two molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia ...
Biology /
Jan 28, 2009 |
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