Artificial enzyme can activate a gene switch

Complex reaction cascades can be triggered in artificial molecular systems: Swiss scientists have constructed an enzyme than can penetrate a mammalian cell and accelerate the release of a hormone. This then activates a gene ...

Kill switches for engineered microbes gone rogue

Synthetic biologists are fitting the genomes of microorganisms with synthetic gene circuits to break down polluting plastics, non-invasively diagnose and treat infections in the human gut, and generate chemicals and nutrition ...

Uncovering a reversible master switch for development

In a paper published in Genes & Development, BWH principal investigator Mitzi Kuroda, PhD, and her team identified a reversible "master switch" on most developmental genes. The team unearthed this biological insight through ...

Controlling gene activity in human development

Researchers at the Babraham Institute have revealed a new understanding of the molecular switches that control gene activity in human embryonic stem cells. This insight provides new avenues for improving the efficiency of ...

Researchers use CRISPR to create 'kill switch' for GMOs

(Phys.org)—A pair of researchers at MIT has developed what amounts to a "kill switch" for genetically modified organisms (GMOs). In their paper published in the journal Nature Communications, Brian Caliando and Christopher ...

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