Related topics: proceedings of the national academy of sciences , protein , cancer , genome , gene expression
Gene
hideA gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain their cells and pass genetic traits to offspring. A modern working definition of a gene is "a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions, and or other functional sequence regions " . In common usage, the term gene often refers to what is known more accurately as an allele.
The notion of a gene has evolved with the science of genetics, which began when Gregor Mendel noticed that biological variations are inherited from parent organisms as specific, discrete traits. The biological entity responsible for defining traits was termed a gene, but the biological basis for inheritance remained unknown until DNA was identified as the genetic material in the 1940s. All organisms have many genes corresponding to many different biological traits, some of which are immediately visible, such as eye color or number of limbs, and some of which are not, such as blood type or increased risk for specific diseases, or the thousands of basic biochemical processes that comprise life.
In cells, a gene is a portion of DNA that contains both "coding" sequences that determine what the gene does, and "non-coding" sequences that determine when the gene is active (expressed). When a gene is active, the coding and non-coding sequences are copied in a process called transcription, producing an RNA copy of the gene's information. This piece of RNA can then direct the synthesis of proteins via the genetic code. In other cases, the RNA is used directly, for example as part of the ribosome. The molecules resulting from gene expression, whether RNA or protein, are known as gene products, and are responsible for the development and functioning of all living things.
In more technical terms, a gene is a locatable region of genomic sequence, corresponding to a unit of inheritance, and is associated with regulatory regions, transcribed regions and/or other functional sequence regions. The physical development and phenotype of organisms can be thought of as a product of genes interacting with each other and with the environment. A concise definition of a gene, taking into account complex patterns of regulation and transcription, genic conservation and non-coding RNA genes, has been proposed by Gerstein et al.: "A gene is a union of genomic sequences encoding a coherent set of potentially overlapping functional products".
For more information about Gene, read the full article at
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News tagged with genes
Scientists discover 2 genes that drive aggressive brain cancers
Dec 23, 2009 |
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A team of Columbia scientists have discovered two genes that, when simultaneously activated, are responsible for the most aggressive forms of human brain cancer.
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Scientists identify protein that keeps stem cells poised for action
Dec 24, 2009 |
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Like a child awaiting the arrival of Christmas, embryonic stem cells exist in a state of permanent anticipation. They must balance the ability to quickly become more specialized cell types with the cellular chaos that could ...
'Self-seeding' of cancer cells may play a critical role in tumor progression
Dec 24, 2009 |
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Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by metastasis, in which cancer cells leave the primary tumor and spread to distant organs. A new study by researchers ...
Citrus surprise: Vitamin C boosts the reprogramming of adult cells into stem cells
Dec 24, 2009 |
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Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, ...
Genomic toggle switches divide autoimmune diseases into distinct clusters
Dec 23, 2009 |
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Genomic switches can predispose an individual to one set of autoimmune disorders but protect the same person against another set of them, scientists at Stanford University School of Medicine have found.
Scientists show that plants have measure of the shortest day
Dec 23, 2009 |
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(PhysOrg.com) -- It is not only people who feel the effects of short winter days - new research by the University of Edinburgh and the University of Warwick has shed light on how plants calculate their own winter solstice. ...
A novel gene found for childhood-onset asthma
Dec 23, 2009 |
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Pediatric researchers have identified a novel gene involved in childhood asthma, in one of the largest gene studies to date of the common respiratory disease. Because the gene, called DENND1B, affects cells and signaling ...
Genomic differences identified in common skin diseases
Dec 23, 2009 |
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(PhysOrg.com) -- If you have dry skin, wet it, if wet skin, dry it. This has been a general rule of dermatology for centuries, but scientists are working to develop more precise treatments for the dozen-plus inflammatory ...
Broken genomes behind breast cancers
Dec 23, 2009 |
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The first detailed search of breast cancer genomes to uncover genomic rearrangements is published today. The team characterised the ways in which the human genome is broken and put back together in 24 cases of breast cancer.
First volume of microbial encyclopedia published
Dec 23, 2009 |
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The Earth is estimated to have about a nonillion (1030) microbes in, on, around, and under it, comprised of an unknown but very large number of distinct species. Despite the widespread availability of microbi ...
Synergistic interaction enhances pathogenesis of Parkinson's disease
Dec 23, 2009 |
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Scientists have identified a synergistic interaction that disrupts normal intracellular transport mechanisms and leads to the accumulation of neuron-damaging clumps of protein associated with Parkinson's disease (PD), a neurodegenerative ...
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