News tagged with genetic models
Neurobiologists identify animal model for a deadly human metabolic disorder
In medical research, finding a reliable and cost-effective animal model can greatly enhance success in identifying disease mechanisms and genetic pathways, potentially cutting years off drug testing regimes and development ...
Medicine & Health / Neuroscience
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Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells
A research group including Kyoto University researchers demonstrates that mouse iPS cells, in which genetic correction occurs spontaneously through mitotic recombination, is selectable from the population of genetically mutated ...
Feb 10, 2012 |
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Researchers discover method to unravel malaria's genetic secrets
The parasite that causes malaria is a genetic outlier, which has prevented scientists from discovering the functions of most of its genes. Researchers at National Jewish Health and Yale University School of Medicine have ...
Jan 25, 2012 |
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Investigators achieve important step toward treating Huntington's disease
A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary ...
Medicine & Health / Neuroscience
Jan 19, 2012 |
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Researchers identify genetic signatures of exceptional longevity in re-published study
While environment and family history are factors in healthy aging, genetic variants play a critical and complex role in conferring exceptional longevity, according to researchers from the Boston University Schools of Public ...
Jan 18, 2012 |
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Studies uncover keys in sudden cardiac death
Researchers in Rhode Island Hospital's Cardiovascular Research Center have published two new studies focusing on the causes of arrhythmia and sudden cardiac death (SCD) when a genetic disorder is present. ...
Medicine & Health / Cardiology
Jan 17, 2012 |
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Study finds two genes affect anxiety, behavior in mice with too much MeCP2
The anxiety and behavioral issues associated with excess MeCP2 protein result from overexpression of two genes (Crh [corticotropin-releasing hormone] and Oprm 1 [mu-opioid receptor MOR 1]), which may point the way to treating ...
Jan 08, 2012 |
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Severe congenital disorder successfully treated in a mouse model for the first time
Using a mouse model, Heidelberg University Hospital researchers have for the first time successfully treated a severe congenital disorder in which sugar metabolism is disturbed. The team headed by Prof. Christian Korner, ...
Dec 22, 2011 |
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Tissue structure delays cancer development
Cancer growth normally follows a lengthy period of development. Over the course of time, genetic mutations often accumulate in cells, leading first to pre-cancerous conditions and ultimately to tumour growth. Using a mathematical ...
Dec 19, 2011 |
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Disease progression halted in rat model of Lou Gehrig's disease
Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations are the cause of disease in 5% of patients ...
Dec 12, 2011 |
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New strain of lab mice mimics human alcohol consumption patterns
A line of laboratory mice developed by a researcher from the School of Science at Indiana University-Purdue University Indianapolis drinks more alcohol than other animal models and consumes it in a fashion ...
Dec 12, 2011 |
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Aging human bodies and aging human oocytes run on different clocks
Reproductive and somatic aging use different molecular mechanisms that show little overlap between the types of genes required to keep oocytes healthy and the genes that generally extend life span, according to Coleen Murphy, ...
Dec 06, 2011 |
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Powerful mathematical model greatly improves predictions for species facing climate change
UCLA life scientists and colleagues have produced the most comprehensive mathematical model ever devised to track the health of populations exposed to environmental change.
Dec 03, 2011 |
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Researchers engineer blood stem cells to fight melanoma
Researchers from UCLA's cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. The researchers ...
Nov 28, 2011 |
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Cleft lip corrected genetically in mouse model
Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way ...
Nov 28, 2011 |
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