News tagged with genome stability
Enzyme key to 'sister act' that maintains genome stability
Jul 10, 2008 |
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Keeping the genome stable is a "sister act" of matched chromatids – the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle.
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Researchers illuminate mechanisms that regulate DNA damage control and replication
Biology /
Jan 05, 2009 |
3 / 5 (1) |
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Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating ...
New insight into Bloom's syndrome
Oct 14, 2008 |
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Two independent papers in the October 15th issue of G&D detail the discovery of a previously unidentified fourth component of the Bloom's syndrome complex.
Protein 'chatter' linked to cancer activation
Aug 13, 2007 |
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Scientists have found the existence of cross-talk between human chromosome ends and the protein complexes central to the stability of the entire human genome, a “chat” that contributes to cancer development.
Gene variants may help to distribute the work of evolution between men and women
Biology /
Jan 31, 2008 |
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Scientists from deCODE genetics today report the discovery of two common, single-letter variants in the sequence of the human genome (SNPs) that regulate one of the principle motors of evolution. Versions of the two SNPs, ...
Mimicry at the molecular level protects genome integrity
Apr 13, 2009 |
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The new study, which was published on April 12, 2009, in an advanced online edition of the journal Nature Structural & Molecular Biology, draws new parallels between the Rad60 DNA repair factor and SUMO, a small ubiquitin-like modifi ...
Two proteins act as molecular tailors in DNA repair
Nov 13, 2009 |
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(PhysOrg.com) -- On average, our cells encounter a very lethal form of DNA damage 10 times a day. Lucky for us, we have the capacity to repair each and every one of them. New research now reveals exactly how two well-known ...
Beyond a 'speed limit' on mutations, species risk extinction
Biology /
Oct 01, 2007 |
4.5 / 5 (14) |
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Harvard University scientists have identified a virtual "speed limit" on the rate of molecular evolution in organisms, and the magic number appears to be 6 mutations per genome per generation -- a level beyond which species ...
Australian researchers first in the world to solve the genetic code of canola
Nov 06, 2009 |
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(PhysOrg.com) -- Until recently, the genetic code of canola was a mystery. Australian researcher Dr David Edwards, in collaboration with Bayer CropScience and Keygene N.V., is the first in the world to have solved the code, ...
Mutations within a conservative region of HCV affects the therapy
Mar 30, 2009 |
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At least 200 million individuals are currently infected with hepatitis C virus (HCV) worldwide. Approximately 30%-50% of patients respond to interferon/ribavirin combination therapy. Response to interferon therapy depends ...
New discovery linked to DNA repair and cancer
May 01, 2008 |
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Scientists have discovered a new protein in humans that plays an important role in repairing DNA damage that could lead to cancer.
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