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Myocardial infarction

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Myocardial infarction (MI or AMI for acute myocardial infarction), commonly known as a heart attack, occurs when the blood supply to part of the heart is interrupted causing some heart cells to die. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (like cholesterol) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and oxygen shortage, if left untreated for a sufficient period of time, can cause damage and / or death (infarction) of heart muscle tissue (myocardium).

Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). Women may experience fewer typical symptoms than men, most commonly shortness of breath, weakness, a feeling of indigestion, and fatigue. Approximately one quarter of all myocardial infarctions are silent, without chest pain or other symptoms. A heart attack is a medical emergency, and people experiencing chest pain are advised to alert their emergency medical services, because prompt treatment can be crucial to survival.

Heart attacks are the leading cause of death for both men and women all over the world. Important risk factors are previous cardiovascular disease (such as angina, a previous heart attack or stroke), older age (especially men over 40 and women over 50), tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein or "bad cholesterol") and low levels of high density lipoprotein (HDL, "good cholesterol"), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine and methamphetamine), and chronic high stress levels.

Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual glyceryl trinitrate (colloquially referred to as nitroglycerin and abbreviated as NTG or GTN). Pain relief is also often given, classically morphine sulfate. A 2009 review however about the use of high flow oxygen for treating myocardial infarction found its administration increased mortality and infarct size, calling into question the recommendation for its routine use.

The patient will receive a number of diagnostic tests, such as an electrocardiogram (ECG, EKG), a chest X-ray and blood tests to detect elevations in cardiac markers (blood tests to detect heart muscle damage). The most often used markers are the creatine kinase-MB (CK-MB) fraction and the troponin I (TnI) or troponin T (TnT) levels. On the basis of the ECG, a distinction is made between ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI). Most cases of STEMI are treated with thrombolysis or if possible with percutaneous coronary intervention (PCI, angioplasty and stent insertion), provided the hospital has facilities for coronary angiography. NSTEMI is managed with medication, although PCI is often performed during hospital admission. In patients who have multiple blockages and who are relatively stable, or in a few extraordinary emergency cases, bypass surgery of the blocked coronary artery is an option.

The phrase "heart attack" is sometimes used incorrectly to describe sudden cardiac death, which may or may not be the result of acute myocardial infarction. A heart attack is different from, but can be the cause of cardiac arrest, which is the stopping of the heartbeat, and cardiac arrhythmia, an abnormal heartbeat. It is also distinct from heart failure, in which the pumping action of the heart is impaired; severe myocardial infarction may lead to heart failure, but not necessarily.

For more information about Myocardial infarction, read the full article at Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.


News tagged with heart attack

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Ginkgo biloba doesn’t prevent cardiovascular events but may have potential peripheral artery disease benefits

Medicine & Health / Research

created Nov 26, 2009 | popularity 4.5 / 5 (2) | comments 0

(PhysOrg.com) -- Ginkgo biloba didn’t prevent cardiovascular death or major events such as heart attack and stroke in people age 75 and older, but the herb may affect peripheral vascular disease, according to research reported ...


Dentists can help to identify patients at risk of a heart attack

Medicine & Health / Diseases

created Nov 25, 2009 | popularity not rated yet | comments 0

Dentists can help to identify patients who are in danger of dying of a heart attack or stroke, reveals a new study from the Sahlgrenska Academy. Thanks to the study, six men who thought they were completely healthy were able ...


High vs. low hospital volume for angioplasty finds little difference in death rates

Medicine & Health / Other

created Nov 24, 2009 | popularity not rated yet | comments 0

A study based on a contemporary registry of patients with myocardial infarction (heart attack) indicates that even though hospitals that perform a higher number of angioplasties are more likely to follow evidence-based guidelines ...


Bottling up work woes increases heart risk: study

Medicine & Health / Health

created Nov 24, 2009 | popularity 4 / 5 (1) | comments 0

Men who bottle up frustrations about unfair treatment at work are twice as likely to have a heart attack, a study published in Britain on Tuesday suggests.


Abnormal cholesterol levels may raise risk of heart failure

Medicine & Health / Health

created Nov 23, 2009 | popularity 5 / 5 (1) | comments 0

(PhysOrg.com) -- Even if you never have a heart attack, abnormal blood cholesterol levels may significantly raise your risk of heart failure, according to research reported in Circulation: Journal of the American Heart As ...


Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which

Stable plaque or heart attack plaque? Researcher builds new MEMS sensor to tell which is which

Medicine & Health / Research

created Nov 23, 2009 | popularity not rated yet | comments 0

University of Sourthern California biomedical engineer and cardiologist Tzung "John" Hsiai hopes to develop a new tool to help clinicians distinguish cardiac emergencies requiring immediate surgery from chronic ...


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Alcohol helps lower heart disease risk for men: study

Medicine & Health / Health

created Nov 19, 2009 | popularity 4.3 / 5 (7) | comments 7

Men who drink alcohol every day see a nearly one-third average reduction in the risk of coronary heart disease, according to a long-term study among Spanish men published on Thursday.


Study: CT scans rule out heart attacks faster

Medicine & Health / Other

created Nov 18, 2009 | popularity 5 / 5 (1) | comments 0

(AP) -- A new study suggests that a type of "super X-ray" can give a faster, cheaper way to tell whether a chest pain sufferer is really having a heart attack.


Hospital report cards do not appear to result in significant improvements

Medicine & Health / Other

created Nov 18, 2009 | popularity not rated yet | comments 0

An analysis of quality of cardiac care following the public release of data on measures of care at hospitals in Ontario, Canada, did not result in significant systemwide improvement in hospitals' performance on most quality ...


New Test May Predict Heart Disease Events and the Effect of Weight Loss on Insulin Resistance

Medicine & Health / Research

created Nov 17, 2009 | popularity 5 / 5 (1) | comments 0

(PhysOrg.com) -- Chemical fingerprints produced by the body's normal metabolic processes predict who will suffer cardiovascular events and who will benefit from weight loss by reduction of insulin resistance, according two ...


Heart disease found in Egyptian mummies

Heart disease found in Egyptian mummies

Other Sciences / Archaeology & Fossils

created Nov 17, 2009 | popularity not rated yet | comments 0

Hardening of the arteries has been detected in Egyptian mummies, some as old as 3,500 years, suggesting that the factors causing heart attack and stroke are not only modern ones; they afflicted ancient people, ...


FDA says heartburn drugs can interfere with Plavix (AP)

FDA says heartburn drugs can interfere with Plavix

Medicine & Health / Medications

created Nov 17, 2009 | popularity not rated yet | comments 0

(AP) -- Federal health officials said Tuesday a popular variety of heartburn medications can interfere with the blood thinner Plavix, a drug taken by millions of Americans to reduce risks of heart attack ...


New Anti-Clotting Medication Not More Effective than Standard Care; Hint of Other Clinical Benefits

Medicine & Health / Medications

created Nov 17, 2009 | popularity not rated yet | comments 0

(PhysOrg.com) -- Two large studies confirmed that an investigational, reversible anti-clotting medication failed to show greater effectiveness than clopidogrel or a placebo for patients undergoing a procedure to open blocked ...


Exercise-linked ventricular tachycardia is not a risk to healthy older adults

Medicine & Health / Research

created Nov 17, 2009 | popularity 4.5 / 5 (2) | comments 0

Healthy, older adults free of heart disease need not fear that bouts of rapid, irregular heartbeats brought on by vigorous exercise might increase short- or long-term risk of dying or having a heart attack, according to a ...


Marker of oxidative stress predicts heart disease outcomes

Medicine & Health / Research

created Nov 17, 2009 | popularity 5 / 5 (1) | comments 0

Judging from the number of juices and teas advertised as containing antioxidants, consumers are aware of the dangers of oxidative stress. But what is the best way to measure it - and fight it?