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News tagged with hematopoietic stem cells
Study unlocks origins of blood stem cells
A research team led by Nancy Speck, PhD, professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania, has discovered a molecular marker for the immediate ...
Dec 09, 2011 |
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Aging stem cells may explain higher prevalence of leukemia, infections among elderly
Human stem cells aren't immune to the aging process, according to scientists at the Stanford University School of Medicine. The researchers studied hematopoietic stem cells, which create the cells that comprise the blood ...
Nov 28, 2011 |
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Phase I trial begins using gene therapy and bone marrow stem cells in the treatment of brain cancer
University Hospitals (UH) Case Medical Center, Case Western Reserve University School of Medicine and Lentigen Corporation announced today the initiation of a novel Phase I clinical trial of LG631 gene therapy for the protection ...
Nov 14, 2011 |
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3-D long-term bone marrow culture to analyze stromal cell biological function
Stromal cells, as distinct from hematopoietic cells, are an essential component of the bone marrow microenvironment and are necessary for the long-term maintenance of hematopoietic stem cells (HSCs) in vitro. Previous studies ...
Nov 02, 2011 |
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Modeling cancer using ecological principles
The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal Theoretical Biology and Medical Mo ...
Oct 03, 2011 |
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Scientists successfully expand bone marrow-derived stem cells in culture
All stem cells -- regardless of their source -- share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic (or blood-forming) ...
Sep 15, 2011 |
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Researchers successfully perform first injection of cultured red blood cells in human donor
For the first time, researchers have successfully injected cultured red blood cells (cRBCs) created from human hematopoietic stem cells (HSCs) into a human donor, according to study results published today in Blood, the Journal of the American Society of Hematology (ASH). As the ...
Sep 01, 2011 |
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Stem cells central to pathogenesis of mature lymphoid tumors
New research suggests that blood stem cells can be involved in the generation of leukemia, even when the leukemia is caused by the abnormal proliferation of mature cells. The study, published by Cell Press in the August 16th ...
Aug 15, 2011 |
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Researchers parse the origins of hematopoietic stem cells
Researchers at the University of California, San Diego School of Medicine have identified a gene and a novel signaling pathway, both critical for making the first hematopoietic stem cells (HSCs) in developing ...
Jun 08, 2011 |
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Team demonstrates breakthrough method of stem cell expansion
(Medical Xpress) -- Researchers in the Department of Pathology at Stony Brook University School of Medicine have discovered a laboratory method to expand adult hematopoietic stem cells (HSCs) using the SALL4 ...
Jun 07, 2011 |
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Researchers develop platform to monitor hematopoietic stem cells
A Canadian research team has developed an automated microfluidic cell culture platform to monitor the growth, survival and responses of hundreds of hematopoietic stem cells (HSCs) at the single cell level.
May 22, 2011 |
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Enhanced cord blood stem cell transplants safe in long-term studies
(Medical Xpress) -- An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report ...
Medicine & Health / Medications
Apr 18, 2011 |
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Prostate cancer spreads to bones by overtaking the home of blood stem cells
Like bad neighbors who decide to go wreck another community, prostate and breast cancer usually recur in the bone, according to a new University of Michigan study.
Mar 23, 2011 |
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How long do stem cells live?
When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed when a patient is low on red blood cells, as in anemia, or white blood cells, which ...
Mar 01, 2011 |
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Unappreciated dynamism of blood cell production
The bone marrow stem cells responsible for generating new blood cells are less fixed and more flexible than previously thought, according to a paper published online on February 7 in the Journal of Experimental Medicine.
Feb 07, 2011 |
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Hematopoietic stem cell
Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.
For more information about Hematopoietic stem cell, read the full article at
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