News tagged with inhibitors
Drug shows promise for T315I-mutated chronic myeloid leukemia
Dec 07, 2009 |
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Results from a phase II clinical trial indicate a novel drug may provide a treatment option for chronic myeloid leukemia (CML) patients who do not respond to current therapies, researchers from The University of Texas M. ...
Researchers identify new mechanism of blocking HIV-1 from entering cells
Medicine & Health / HIV & AIDS
Nov 30, 2009 |
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Publishing in PLoS Pathogens, researchers at from the Kimmel Cancer Center at Jefferson have found a novel mechanism by which drugs block HIV-1 from entering host cells.
A new mouse could help understand how some lung cancer cells evade drug treatment
Dec 09, 2009 |
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Lung cancer is the leading cause of cancer mortality worldwide and lung adenocarcinoma is the most common type. Many cases of lung adenocarcinoma are attributed to a mutation in a gene for the epidermal growth factor receptor ...
Second-line CML drugs evoke faster response than front-line therapy
Dec 07, 2009 |
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Two medications approved as treatment for drug-resistant chronic myeloid leukemia continue to provide patients with quicker, better responses as a first treatment than the existing front-line drug, researchers at The University ...
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Emerald BioStructures announces discovery of small molecule modulators of PDE4
Dec 27, 2009 |
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Emerald BioStructures (formerly deCODE biostructures) announced a publication in the December 27, 2009 advance online issue of Nature Biotechnology, detailing the application of structure-based drug design (SBDD) to engine ...
Figitumumab has anti-tumor activity in Ewing's sarcoma
Dec 23, 2009 |
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A preliminary study of the anticancer drug figitumumab has found that it has antitumour activity in Ewing's sarcoma—a cancer which affects mainly teenage boys. The results have led to the drug's progression to a Phase 2 trial ...
Research yields new agent for some drug-resistant non-small cell lung cancers
Dec 23, 2009 |
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The ability to make, test, and map the atomic structure of new anti-cancer agents has enabled a team of Dana-Farber Cancer Institute scientists to discover a compound capable of halting a common type of drug-resistant ...
Disparity in use of implantable devices to prevent sudden death in heart failure patients
Dec 18, 2009 |
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A study of heart failure patients who meet national guidelines for devices that stabilize and strengthen the heart's electrical system found that only half of eligible patients received the devices. The study, which is the ...
Enzyme may create new approach to hypertension therapy
Dec 17, 2009 |
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New research from the Northwestern University Feinberg School of Medicine has found that an alternative therapy may be possible for treating some types of hypertension using an enzyme called ACE2.
Invasion without a stir
Dec 17, 2009 |
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Bacteria of the genus Salmonella cause most food-borne illnesses. The bacteria attach to cells of the intestinal wall and induce their own ingestion by cells of the intestinal epithelium. Up till now, researchers assumed ...
Low cholesterol transfer protein activity associated with heart disease risk
Dec 15, 2009 |
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Although seen as a potential heart disease therapy, raising high-density lipoprotein (HDL) cholesterol levels by inhibiting activity of a transfer protein may not be effective, a new study suggests. Scientists at the Jean ...
Targeting brain cancer cell metabolism may provide new treatment
Dec 15, 2009 |
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Inhibiting fatty acid synthesis in brain cancer cells may offer a new option to treat about 50 percent of deadly glioblastomas that are driven by amplified signaling of the epidermal growth factor receptor (EGFR), according ...
Antidepressants may increase risk of stroke and death
Medicine & Health / Medications
Dec 14, 2009 |
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Postmenopausal women who take antidepressants face a small but statistically significant increased risk for stroke and death compared with those who do not take the drugs. The new findings are from the federally-funded, multi-institution, ...
Clinical trial advances new approach to re-sensitizing breast cancer
Dec 13, 2009 |
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A new drug cocktail might be the right mix to fight breast cancer after it becomes resistant to standard therapy. Details of a new study supporting this approach suggest it's possible to re-sensitize tumors thus allowing ...
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