Related topics: type 2 diabetes , diabetes , cell metabolism , insulin , blood sugar
Insulin resistance
hideInsulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.
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News tagged with insulin resistance
Arizona State and Mayo Clinic partner to combat metabolic syndrome
Dec 17, 2009 |
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Arizona State University and Mayo Clinic in Arizona are joining forces in a partnership to investigate metabolic syndrome - a cluster of high-risk medical factors that include increased blood pressure, elevated insulin levels, ...
High-fat low-carb diets could mean significant heart risk
Dec 09, 2009 |
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New scientific research has shown that low-carbohydrate high-fat diets, made popular by the likes of the Atkins diet, do not achieve more weight loss than low-fat high-carbohydrate diets. Worryingly, the research, lead by ...
College football linemen take one for the team in terms of health
Dec 07, 2009 |
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The high-intensity exercise performed by college football linemen does not protect them from obesity, related health problems and the potential for cardiovascular disease later in life, new research suggests.
Cardiovascular risk in youth with type 1 diabetes linked primarily to insulin resistance
Dec 01, 2009 |
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According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), youth with type 1 diabetes have now been found to have abnormal insulin resistance. Having abnor ...
Molecule discovered that makes obese people develop diabetes
Nov 24, 2009 |
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Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. A European research team has now discovered that obese people have large amounts of the ...
Systems biology approach provides insulin resistance insights
Nov 23, 2009 |
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Researchers from the University of California, San Diego recently offered the sharpest-yet picture of how core biochemical pathways in skeletal muscle cells and fat cells are altered in people who suffer from ...
New Test May Predict Heart Disease Events and the Effect of Weight Loss on Insulin Resistance
Nov 17, 2009 |
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(PhysOrg.com) -- Chemical fingerprints produced by the body's normal metabolic processes predict who will suffer cardiovascular events and who will benefit from weight loss by reduction of insulin resistance, according two ...
Scientists create fruit fly model to help unravel genetics of human diabetes
Nov 02, 2009 |
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As rates of obesity, diabetes, and related disorders have reached epidemic proportions in the US in recent years, scientists are working from many angles to pinpoint the causes and contributing factors involved ...
A nervous system drug-by-design
Oct 26, 2009 |
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Working like an architect, Prof. Hagit Eldar-Finkelman of Tel Aviv University's Sackler School of Medicine is "building" a new drug, L803-MTS, to treat a number of central nervous system (CNS) diseases like Alzheimer's. In ...
Innovative program helps treat depression and obesity
Oct 19, 2009 |
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(PhysOrg.com) -- A University of Queensland pilot study to evaluate the effectiveness of an innovative traditional Chinese exercise program on depression and obesity has produced very promising results.
Could antioxidants make us more, not less, prone to diabetes? Study says yes
Oct 06, 2009 |
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We've all heard about the damage that reactive oxygen species (ROS) - aka free radicals - can do to our bodies and the sales pitches for antioxidant vitamins, skin creams or "superfoods" that can stop them. In fact, there ...
Ethnic background may be associated with diabetes risk
Oct 06, 2009 |
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Fat and muscle mass, as potentially determined by a person's ethnic background, may contribute to diabetes risk, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & ...
High-fat diet impairs muscle health before impacting function
Oct 06, 2009 |
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(PhysOrg.com) -- Skeletal muscle plays a critical role in regulating blood sugar levels in the body. But few studies have comprehensively examined how obesity caused by a high-fat diet affects the health of muscle in adolescents ...
Insulin boost restores muscle growth in elderly
Sep 25, 2009 |
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When most people think of insulin, they think of diabetes — a disease that arises when, for one reason or another, insulin can't do the critical job of helping the body process sugar. But the hormone has another, less well-known ...
Diabetes drug shows promise in fighting lethal cancer complication
Sep 24, 2009 |
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Insulin resistance, the hallmark of type 2 diabetes and a condition often associated with obesity, is paradoxically also an apparent contributor to muscle wasting and severe fat loss that accompanies some cancers, according ...
