Related topics: type 2 diabetes , diabetes , cell metabolism , insulin , blood sugar
Insulin resistance
hideInsulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.
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News tagged with insulin resistance
Systems biology approach provides insulin resistance insights
Nov 23, 2009 |
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Researchers from the University of California, San Diego recently offered the sharpest-yet picture of how core biochemical pathways in skeletal muscle cells and fat cells are altered in people who suffer from ...
High-fat low-carb diets could mean significant heart risk
Dec 09, 2009 |
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New scientific research has shown that low-carbohydrate high-fat diets, made popular by the likes of the Atkins diet, do not achieve more weight loss than low-fat high-carbohydrate diets. Worryingly, the research, lead by ...
College football linemen take one for the team in terms of health
Dec 07, 2009 |
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The high-intensity exercise performed by college football linemen does not protect them from obesity, related health problems and the potential for cardiovascular disease later in life, new research suggests.
Molecule discovered that makes obese people develop diabetes
Nov 24, 2009 |
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Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. A European research team has now discovered that obese people have large amounts of the ...
Arizona State and Mayo Clinic partner to combat metabolic syndrome
Dec 17, 2009 |
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Arizona State University and Mayo Clinic in Arizona are joining forces in a partnership to investigate metabolic syndrome - a cluster of high-risk medical factors that include increased blood pressure, elevated insulin levels, ...
Cardiovascular risk in youth with type 1 diabetes linked primarily to insulin resistance
Dec 01, 2009 |
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According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), youth with type 1 diabetes have now been found to have abnormal insulin resistance. Having abnor ...
