Insulin resistance
hideInsulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.
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News tagged with insulin sensitivity
Think what you eat: Studies point to cellular factors linking diet and behavior
Medicine & Health / Neuroscience
Oct 20, 2009 |
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New research released today is affirming a long-held maxim: you are what you eat — and, more to the point, what you eat has a profound influence on the brain. The findings offer insight into the neurobiological factors behind ...
Diabetes drug kills cancer stem cells in combination treatment in mice
Sep 14, 2009 |
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In a one-two punch, a familiar diabetes drug reduced tumors faster and prolonged remission in mice longer than chemotherapy alone by targeting cancer stem cells, Harvard Medical School researchers reported in the September ...
Exercise alone shown to improve insulin sensitivity in obese sedentary adolescents
Sep 01, 2009 |
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A moderate aerobic exercise program, without weight loss, can improve insulin sensitivity in both lean and obese sedentary adolescents, according to a new study accepted for publication in The Endocrine Society's Journal of ...
Peptide linked to glucose metabolism and neuronal cell survival (w/ Video)
Jul 22, 2009 |
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A cellular protein that may prevent nerve cells from dying also helps to improve insulin action and lower blood glucose levels, according to a study by researchers at Albert Einstein College of Medicine of ...
Researchers find genetic markers to help fight diabetes
Jun 16, 2009 |
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Translational Genomics Research Institute (TGen) scientists have identified five genetic biomarkers that could help lead to improved treatments, with fewer side-effects, for patients with diabetes.
Researchers first to document early signs for diabetes in kids as young as 7
Jun 08, 2009 |
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Research conducted under the direction of Melinda Sothern, PhD, Professor and Director of Health Promotion at the LSU Health Sciences Center New Orleans School of Public Health, showing early signs of diabetes in healthy ...
Walking often and far reduces risks in heart patients
May 11, 2009 |
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An exercise program that burns a lot of calories reduced cardiac risk factors better than standard cardiac rehabilitation in overweight coronary patients, researchers report in Circulation: Journal of the American Heart As ...
Calorie restriction causes temporal changes in liver metabolism
May 04, 2009 |
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Moderate calorie restriction causes temporal changes in the liver and skeletal muscle metabolism, whereas moderate weight loss affects muscle, according to a new study in Gastroenterology, the official journal of the Americ ...
Gene therapy shows early promise for treating obesity
Mar 09, 2009 |
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With obesity reaching epidemic levels, researchers at the Ohio State University Medical Center are studying a potentially long-term treatment that involves injecting a gene directly into one of the critical feeding and weight ...
Insulin is a possible new treatment for Alzheimer's
Feb 02, 2009 |
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A Northwestern University-led research team reports that insulin, by shielding memory-forming synapses from harm, may slow or prevent the damage and memory loss caused by toxic proteins in Alzheimer's disease.
Trans-fatty acids and insulin sensitivity
Jul 08, 2008 |
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Trans-fatty acids have been the topic of a lot of negative health news, but in the July Journal of Lipid research, a dietary study in rats suggests that trans-fats do not increase the risk of insulin resistance and diabet ...
