Interleukin 6
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Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery (Petersen, J Appl Physiol 2005). Additionally, osteoblasts secrete IL-6 to stimulate osteoblast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.
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News tagged with interleukin 6
Thoughtful words help couples stay fighting fit
Medicine & Health / Psychology & Psychiatry
Nov 13, 2009 |
3.5 / 5 (2) |
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Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
Researchers Study Whether Psychosocial Interventions Ease Psoriasis
Nov 11, 2009 |
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(PhysOrg.com) -- The National Center for Complementary and Alternative Medicine has awarded University of Rochester Medical Center researchers $2.5 million to investigate the impact of psychological interventions on attacks ...
Depression predicts increases in inflammatory protein linked to heart disease
Medicine & Health / Psychology & Psychiatry
Oct 05, 2009 |
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1
(PhysOrg.com) -- Which comes first, depression or inflammation? To help solve this long standing chicken and egg conundrum, researchers led by Jesse Stewart, Ph.D., assistant professor of psychology at Indiana ...
You must remember this: Scientists develop nasal spray that improves memory
Oct 01, 2009 |
3.4 / 5 (11) |
4
Good news for procrastinating students: a nasal spray developed by a team of German scientists promises to give late night cram sessions a major boost, if a good night's sleep follows. In a research report featured as the ...
Blocking protein may prevent blinding disease
Sep 16, 2009 |
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Blocking a protein that battles infection may help thwart a common cause of vision loss in chronic diseases such as diabetes, Medical College of Georgia researchers say.
Study suggests that inflammation may be the link between extreme sleep durations and poor health
Feb 02, 2009 |
4 / 5 (1) |
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A study in the Feb. 1 issue of the journal Sleep shows that sleep duration is associated with changes in the levels of specific cytokines that are important in regulating inflammation. The results suggest that inflammation may be ...
2 immune-system proteins linked to colitis-associated cancer
Feb 02, 2009 |
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Recent research from the laboratory of Michael Karin, PhD, at the University of California, San Diego School of Medicine - the first researcher to demonstrate a molecular link between inflammation and cancer - has identified ...
Stress May Hasten The Growth Of Melanoma Tumors But Common Beta-Blocker Medications Might Slow That Progress
Jan 30, 2009 |
5 / 5 (4) |
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For patients with a particularly aggressive form of skin cancer - malignant melanoma - stress, including that which comes from simply hearing that diagnosis, might amplify the progression of their disease.
DNA component can stimulate and suppress the immune response
Jan 27, 2009 |
5 / 5 (2) |
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A component of DNA that can both stimulate and suppress the immune system, depending on the dosage, may hold hope for treating cancer and infection, Medical College of Georgia researchers say.
New tests needed to predict cardiovascular problems in older people more accurately
Jan 09, 2009 |
5 / 5 (1) |
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A long-standing system for assessing the risk of cardiovascular disease amongst older people should be replaced with something more accurate, according to a study published today on bmj.com.
