Journal of Clinical Investigation
hideThe Journal of Clinical Investigation (JCI or J Clin Invest) is a leading biomedical journal, with a 2008 impact factor of 16.559. The journal makes its research articles -- including access to articles back to 1924 -- freely available online.
The website of the journal describes it as "a premier venue for critical advances in biomedical research, authoritative reviews, and commentaries that place research articles in context." The first issue of the journal appeared in 1924, and within a few decades, it had established itself as a reputed journal for primary clinical research.
The JCI's Editorial Board is unique in that its members are located chiefly at a singular academic medical center and are predominantly members of the American Society for Clinical Investigation. The leadership of the Editorial Board changes every five years: As of March 2007, the Editorial Board is located at the University of Pennsylvania under the leadership of Laurence A. Turka, M.D. From March 2002 to March 2007, the Editorial Board was located at Columbia University under the leadership of Andrew Marks, M.D. Ushma S. Neill, formerly with Nature Medicine, is the journal's Executive Editor.
This monthly journal publishes original research and review articles, including periodic review series focusing on important topics in biomedicine.
For more information about Journal of Clinical Investigation, read the full article at
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News tagged with journal of clinical investigation
Study provides first clear idea of how rare bone disease progresses
Nov 12, 2009 |
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An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ...
NSAIDs prevent early sign of Alzheimer disease in mice
Nov 09, 2009 |
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If taking nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen or naproxen is to protect you from developing Alzheimer disease then you will have to start taking them at a very early age according to new research ...
Cellular Source of Most Common Type of Abnormal Heart Beat Found
Nov 02, 2009 |
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(PhysOrg.com) -- While studying how the heart is formed, scientists at the University of Pennsylvania School of Medicine serendipitously found a novel cellular source of atrial fibrillation (AF), the most ...
Immune cells predict outcome of West Nile virus infection
Oct 12, 2009 |
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Infection with West Nile virus (WNV) causes no symptoms in most people. However, it can cause fever, meningitis, and/or encephalitis. What determines the outcome of infection with WNV in different people has not been determined. ...
Iron regulates the TLR4 inflammatory signaling pathway
Oct 05, 2009 |
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Iron is a micronutrient essential to the survival of both humans and disease-causing microbes. Changes in iron levels therefore affect the severity of infectious diseases. For example, individuals with mutations in their ...
Mutated FGFR4 protein helps a childhood cancer spread
Oct 05, 2009 |
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Rhabdomyosarcoma (RMS) is a childhood cancer thought to originate from skeletal muscle. In patients whose disease has spread (metastasized) from the initial tumor site the chance of long-term survival is poor. Hopes for a ...
Immune response to spinal cord injury may worsen damage
Sep 21, 2009 |
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After spinal cord injury, certain immune cells collect in the spinal fluid and release high levels of antibodies. What, if anything, those antibodies do there is unknown.
Experimental Approach May Reverse Rheumatoid Arthritis and Osteoporosis
Sep 21, 2009 |
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(PhysOrg.com) -- Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online today in the Journal of Clinical In ...
What happens when immune cells just won't die?
Sep 14, 2009 |
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X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency most commonly caused by deficiency in the protein SAP.
Ice cream may target the brain before your hips, study suggests
Sep 14, 2009 |
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Blame your brain for sabotaging your efforts to get back on track after splurging on an extra scoop of ice cream or that second burger during Friday night's football game.
Engineered human fusion protein inhibits HIV-1 replication
Sep 08, 2009 |
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In 2004, Jeremy Luban and colleagues from the University of Geneva, Switzerland, reported that New World owl monkeys (Aotus genus) make a fusion protein - AoT5Cyp - that potently blocks HIV-1 infection. The human genome encodes ...
The protein modifier SUMO helps set apart females and males
Sep 02, 2009 |
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One way in which men and women differ is in their expression of liver proteins that control a large number of whole-body processes such as energy generation and lipid and steroid hormone production and turnover. Now, Walter ...
The 'S' stands for surprise: Anticoagulant plays unexpected role in maintaining circulatory integrity
Medicine & Health / Neuroscience
Sep 01, 2009 |
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Protein S, a well-known anticoagulant protein, keeps the blood flowing in more than one way, discovered researchers at the Salk Institute for Biological Studies. The protein contributes to the formation and ...
Tumors Feel the Deadly Sting of Nanobees
Nanotechnology / Bio & Medicine
Aug 28, 2009 |
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When bees sting, they pump into their victims a peptide toxin called melittin that destroys cell membranes. Now, by encapsulating this extremely potent molecule within a nanoparticle, researchers at the Washington University ...
Cellular crosstalk linked to lung disease
Aug 18, 2009 |
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Crosstalk between cells lining the lung (epithelial cells) and airway smooth muscle cells is important in lung development. However, it has also been shown to contribute to several lung diseases, including asthma and pulmonary ...
